2. Gene
  3. IL1RL1 - interleukin 1 receptor like 1 Gene

IL1RL1 - interleukin 1 receptor like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 1 受体样 1

种属: Homo sapiens

同用名: T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R

基因 ID: 9173 | 基因类型: protein coding

关于 IL1RL1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,311,563-102,352,356 (from NCBI)

This gene has 9 transcripts (splice variants), 123 orthologues and 10 paralogues. Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues.

功能概要

由该基因编码的蛋白质是白介素 1 受体家族的成员。对小鼠相似基因的研究表明，该受体可被促炎刺激物诱导，并可能参与辅助性 T 细胞的功能。该基因、白细胞介素 1 受体 I 型 (IL1R1) 、白细胞介素 1 受体 II 型 (IL1R2) 和白细胞介素 1 受体样 2 (IL1RL2) 在映射到染色体 2q12 的区域中形成细胞因子受体基因簇。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

IL1RL1 基因产物(3)

mRNA Protein Name
NM_001282408.2 NP_001269337.1 interleukin-1 receptor-like 1 isoform 3
NM_003856.4 NP_003847.2 interleukin-1 receptor-like 1 isoform 2 precursor
NM_016232.5 NP_057316.3 interleukin-1 receptor-like 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-33 receptor activity IDA
IDA: 通过直接分析推断
16286016 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8621446 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-33-mediated signaling pathway IDA
IDA: 通过直接分析推断
16286016 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL1RL1 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (28 - 103)

Ig_2

Ig_2: Immunoglobulin domain (141 - 201)

Ig_3

Ig_3: Immunoglobulin domain (212 - 307)

TIR

TIR: TIR domain (379 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
蛋白主名 其他名称

interleukin-1 receptor-like 1

growth stimulation-expressed

重组 IL1RL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70615 ST2/IL1RL1 Protein, Human (310a.a, HEK293, His) Q01638-2 (K19-F328) ≥95%
HY-P76090 ST2/IL1RL1 Protein, Human (HEK293) Q01638-2 (K19-F328) ≥95%
HY-P76091 ST2/IL1RL1 Protein, Human (HEK293, Fc) Q01638-2 (K19-F328) ≥95%
HY-P76093 ST2/IL1RL1 Protein, Human (HEK293, His) Q01638-1 (K19-S328) ≥95%

关联疾病

疾病名称 别名
Chicken Egg Allergy

Gallus Gallus Egg Allergy
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Loeffler Syndrome

Loeffler'S Pneumonia

Loffler'S Syndrome

Simple Pulmonary Eosinophilia
Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Chronic Asthma
Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax
Intrinsic Asthma

Non-Atopic Asthma
Respiratory Allergy

Airway Allergy
Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm
Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos
Nasal Cavity Disease

Disorder Of Nasal Cavity
Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99729 Melrilimab Inhibitor 96.07% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06725 IL1RL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IL1RL1 VGNC VGNC:73721
Bos taurus IL1RL1 VGNC VGNC:30134
Felis catus IL1RL1 VGNC VGNC:67768
Rattus norvegicus IL1RL1 RGD RGD:2894
Canis familiaris IL1RL1 VGNC VGNC:41961
Mus musculus IL1RL1 MGD MGI:98427
Macaca fascicularis IL1RL1 NCBI NCBI:102115135
Others IL1RL1 NCBI
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