1. Gene
  2. ZW10 - zw10 kinetochore protein Gene

ZW10 - zw10 kinetochore protein Gene

中文名称:zw10 着丝粒蛋白

种属: Homo sapiens

同用名: HZW10; KNTC1AP

基因 ID: 9183 | 基因类型: protein coding

关于 ZW10

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,733,187-113,773,692 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是许多参与确保细胞分裂过程中染色体正确分离的机制之一。这种蛋白质是有丝分裂检查点的重要组成部分,可防止细胞过早退出有丝分裂。[RefSeq 提供,2011 年 8 月]

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

ZW10 基因产物(1)

mRNA Protein Name
NM_004724.4 NP_004715.1 centromere/kinetochore protein zw10 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11146660 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IGI
IGI: 通过遗传相互作用推断
20163571 GOA
involved in Golgi organization IMP
IMP: 通过突变表型推断
20163571 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
15029241 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: 通过突变表型推断
19468067 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
19468067 GOA
involved in mitotic sister chromatid segregation IDA
IDA: 通过直接分析推断
11146660 GOA
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: 通过直接分析推断
11146660 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
15824131 GOA
involved in protein localization to kinetochore IMP
IMP: 通过突变表型推断
19468067 GOA
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
11146660 GOA
involved in regulation of exit from mitosis IDA
IDA: 通过直接分析推断
11146660 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Dsl1/NZR complex IDA
IDA: 通过直接分析推断
20462495 GOA
part of Dsl1/NZR complex IPI
IPI: 通过物理相互作用推断
20462495 GOA
part of RZZ complex IDA
IDA: 通过直接分析推断
20462495 GOA
part of RZZ complex IPI
IPI: 通过物理相互作用推断
25849506 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15029241 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
11682612 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
11146660 GOA
located in lipid droplet IDA
IDA: 通过直接分析推断
30970241 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15485811 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
11146660 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZW10 蛋白结构

Zw10

Zw10: Centromere/kinetochore Zw10 (9 - 621)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

centromere/kinetochore protein zw10 homolog

ZW10 homolog, centromere/kinetochore protein

ZW10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZW10 O43264 ZWINT Homo sapiens O95229
IF
15824131
种属内
ZW10 O43264 ZWINT Homo sapiens O95229
IF
16732327
种属内
ZW10 O43264 ZWINT Homo sapiens O95229 16732327
种属内
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1 20462495
种属内
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1 20462495
种属内
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1 24056303
种属内
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1
TAP
15824131
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pelger-Huet Anomaly

PHA

Pelger-Huët Anomaly

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

Pelger Huet Anomaly

Pelger-Huet Nuclear Anomaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZW10 VGNC VGNC:48864
Rattus norvegicus ZW10 RGD RGD:1309197
Felis catus ZW10 VGNC VGNC:81067
Bos taurus ZW10 VGNC VGNC:37390
Macaca mulatta ZW10 VGNC VGNC:78915
Mus musculus ZW10 MGD MGI:1349478
Others ZW10 NCBI