2. Gene
  3. RAB11B - RAB11B, member RAS oncogene family Gene

RAB11B - RAB11B, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB11B，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: H-YPT3; NDAGSCW

基因 ID: 9230 | 基因类型: protein coding

关于 RAB11B

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,390,360-8,404,434 (from NCBI)

This gene has 5 transcripts (splice variants), 115 orthologues, 68 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 36.5), thyroid (RPKM 36.2) and 25 other tissues.

功能概要

小 GTP 结合蛋白的 Ras 超家族，包括 Ras (参见 MIM 190020) 、Ral (参见 MIM 179550) 、Rho (参见 MIM 165390) 、Rap (参见 MIM 179520) 和 Rab (参见 MIM 179508) 家族，参与控制一组不同的基本细胞功能。 Rab 家族，包括 RAB11B，似乎在调节胞吐和胞吞途径中发挥关键作用 (Zhu 等人总结，1994 [PubMed 7811277]) 。[OMIM 提供，2010 年 11 月]

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

RAB11B 基因产物(1)

mRNA Protein Name
NM_004218.4 NP_004209.2 ras-related protein Rab-11B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
16545962 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
16545962 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
16545962 GOA
enables myosin V binding IPI
IPI: 通过物理相互作用推断
24006491 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20717956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance by transcytosis IGI
IGI: 通过遗传相互作用推断
26005850 GOA
involved in cellular response to acidic pH IDA
IDA: 通过直接分析推断
20717956 GOA
involved in constitutive secretory pathway IMP
IMP: 通过突变表型推断
14627637 GOA
involved in endocytic recycling IMP
IMP: 通过突变表型推断
19244346 GOA
involved in establishment of protein localization to membrane IMP
IMP: 通过突变表型推断
24006491 GOA
involved in regulation of monoatomic anion transport IMP
IMP: 通过突变表型推断
19244346 GOA
involved in regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
20717956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
21255211 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB11B 蛋白结构

Ras

Ras: Ras family (13 - 173)

  • 0
  • 100
  • 200
  • 218 a.a.
蛋白主名 其他名称

ras-related protein Rab-11B

GTP-binding protein YPT3

重组 RAB11B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74610 RAB11B Protein, Human (HEK293, His) Q15907-1 (G2-C215) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter

NDAGSCW

Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, Decreased Cortical White Matter
Esophagus Sarcoma

Esophageal Sarcoma
Hypotrichosis 3

HYPT3

Hypotrichosis Simplex Of The Scalp 2

Htss2

Hypotrichosis, Type 3
Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum
Rectal Benign Neoplasm

Neoplasm Of Rectum

Rectal Tumor

Rectum Neoplasm

Neoplasm Of The Rectum

Rectal Neoplasms

Primary Rectal Cancer

Rectal Ampulla Cancer

Cancer Of The Rectum

Carcinoma Of Rectum

Primary Malignant Neoplasm Of Rectum

Rectal Cancer

Rectal Carcinoma
Rectum Cancer

Malignant Neoplasm Of Rectum

Rectal Cancer

Cancer Of Rectum

Carcinoma Of Rectum

Carcinoma Of The Rectum

Malignant Rectal Tumor

Malignant Rectum Tumor

Malignant Tumor Of Rectum

Rectal Carcinoma

Rectal Cancers

Cancer, Rectal
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11516 RAB11B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAB11B VGNC VGNC:81518
Mus musculus RAB11B MGD MGI:99425
Felis catus RAB11B VGNC VGNC:97580
Canis familiaris RAB11B VGNC VGNC:45249
Rattus norvegicus RAB11B RGD RGD:68369
Bos taurus RAB11B VGNC VGNC:33615
Others RAB11B NCBI
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