2. Gene
  3. CRB3 - crumbs cell polarity complex component 3 Gene

CRB3 - crumbs cell polarity complex component 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：碎屑细胞极性复杂成分 3

种属: Homo sapiens

基因 ID: 92359 | 基因类型: protein coding

关于 CRB3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,463,777-6,467,221 (from NCBI)

This gene has 4 transcripts (splice variants), 105 orthologues and 3 paralogues. Broad expression in colon (RPKM 9.7), duodenum (RPKM 9.6) and 16 other tissues.

功能概要

该基因编码 Crumbs 蛋白质家族的成员。该基因在上皮组织中广泛表达，其中编码的蛋白质亚型发挥各种作用，例如胞质分裂和纤毛发生的控制或紧密连接的形成。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

CRB3 基因产物(3)

mRNA Protein Name
NM_139161.5 NP_631900.1 protein crumbs homolog 3 isoform a precursor
NM_174881.4 NP_777377.1 protein crumbs homolog 3 isoform b precursor
NM_174882.3 NP_777378.1 protein crumbs homolog 3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
17332497 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17920587 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
17332497 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
17332497 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein crumbs homolog 3

crumbs 3, cell polarity complex component

CRB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRB3 Q9BUF7 EPB41L5 Homo sapiens Q9HCM4
Anti Tag CoIP
17920587
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Charcot-Marie-Tooth Disease Type 4f

CMT4F

Charcot-Marie-Tooth Disease, Type 4f

Charcot-Marie-Tooth Disease 4f

Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4f

Charcot-Marie-Tooth Neuropathy Type 4f

Dejerine-Sottas Disease
Pigmented Paravenous Chorioretinal Atrophy

Pigmented Paravenous Retinochoroidal Atrophy

PPCRA

Pprca

Atrophy, Chorioretinal, Pigmented Paravenous
Retinal Degeneration

Degeneration Of Retina
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03142 CRB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CRB3 MGD MGI:2670904
Rattus norvegicus CRB3 RGD RGD:1565035
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