2. Gene
  3. FANK1 - fibronectin type III and ankyrin repeat domains 1 Gene

FANK1 - fibronectin type III and ankyrin repeat domains 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：纤连蛋白 III 型和锚蛋白重复结构域 1

种属: Homo sapiens

同用名: HSD13

基因 ID: 92565 | 基因类型: protein coding

关于 FANK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,896,564-126,009,592 (from NCBI)

This gene has 10 transcripts (splice variants) and 147 orthologues. Biased expression in testis (RPKM 5.5), thyroid (RPKM 1.2) and 10 other tissues.

功能概要

参与细胞凋亡过程的调节和转录的调节，DNA 模板化。位于细胞质和核质中。与染色质共定位。 [由基因组资源联盟提供，2022 年 4 月]

Involved in regulation of apoptotic process and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

FANK1 基因产物(3)

mRNA Protein Name
NM_001350939.2 NP_001337868.1 fibronectin type 3 and ankyrin repeat domains protein 1 isoform 1
NM_001363549.2 NP_001350478.1 fibronectin type 3 and ankyrin repeat domains protein 1 isoform 3
NM_145235.5 NP_660278.3 fibronectin type 3 and ankyrin repeat domains protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20978819 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20978819 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
20978819 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
27060496 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
27060496 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20978819 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
27060496 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20978819 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20978819 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FANK1 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (114 - 207)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (214 - 308)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

fibronectin type 3 and ankyrin repeat domains protein 1

fibronectin type 3 and ankyrin repeat domains 1

FANK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FANK1 Q8TC84 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
FANK1 Q8TC84 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
FANK1 Q8TC84 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
FANK1 Q8TC84 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
FANK1 Q8TC84 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
FANK1 Q8TC84 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
FANK1 Q8TC84 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
FANK1 Q8TC84 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
FANK1 Q8TC84 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
FANK1 Q8TC84 NEFL Homo sapiens P07196
Y2H Pooling
32814053
种属内
FANK1 Q8TC84 NEFL Homo sapiens P07196
Validated Y2H
32814053
种属内
FANK1 Q8TC84 NEFL Homo sapiens P07196
Y2H Array
32814053
种属内
FANK1 Q8TC84 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
FANK1 Q8TC84 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
FANK1 Q8TC84 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nodular Nonsuppurative Panniculitis

Weber-Christian Disease

Relapsing Febrile Nodular Nonsuppurative Panniculitis

Idiopathic Nodular Panniculitis

Pfeiffer-Weber-Christian Syndrome

Weber-Christian Panniculitis

Panniculitis, Nodular Nonsuppurative

Nodular Non-Suppurative Febrile Panniculitis

Weber - Christian Disease

Panniculitis Nodular Nonsuppurative

Nodular Non-Suppurative Panniculitis

Idiopathic Lobular Panniculitis

Relapsing Febrile Nodular Panniculitis

Wcd
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04742 FANK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FANK1 VGNC VGNC:40726
Bos taurus FANK1 VGNC VGNC:28861
Macaca mulatta FANK1 VGNC VGNC:72559
Mus musculus FANK1 MGD MGI:1914180
Felis catus FANK1 VGNC VGNC:62145
Rattus norvegicus FANK1 RGD RGD:1304756
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