2. Gene
  3. SHKBP1 - SH3KBP1 binding protein 1 Gene

SHKBP1 - SH3KBP1 binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SH3KBP1 结合蛋白 1

种属: Homo sapiens

同用名: Sb1; PP203

基因 ID: 92799 | 基因类型: protein coding

关于 SHKBP1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,576,873-40,591,397 (from NCBI)

This gene has 28 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.5), spleen (RPKM 23.9) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性。预计参与表皮生长因子受体信号通路的正调控。预测位于溶酶体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Predicted to be involved in positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in lysosome. [provided by Alliance of Genome Resources, Apr 2022]

SHKBP1 基因产物(1)

mRNA Protein Name
NM_138392.4 NP_612401.2 SH3KBP1-binding protein 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21145461 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SHKBP1 蛋白结构

BTB_2

BTB_2: BTB/POZ domain (21 - 106)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
蛋白主名 其他名称

SH3KBP1-binding protein 1

SETA-binding protein 1

SHKBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SHKBP1 Q8TBC3 LXN Homo sapiens Q9BS40
Validated Y2H
32296183
种属内
SHKBP1 Q8TBC3 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
SHKBP1 Q8TBC3 CUL3 Homo sapiens Q13618
Y2H
21988832
种属内
SHKBP1 Q8TBC3 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
种属内
SHKBP1 Q8TBC3 SHKBP1 Homo sapiens Q8TBC3
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome
Amelogenesis Imperfecta, Type If

Amelogenesis Imperfecta Type 1f

AI1F

Amelogenesis Imperfecta, Hypoplastic Type If

Amelogenesis Imperfecta Type If

Amelogenesis Imperfecta Hypoplastic Type If

Amelogenesis Imperfecta 1f
Noonan Syndrome 12

NS12
Dieulafoy Lesion

Dieulafoy'S Lesion

Dieulafoy Lesion Of Intestine

Dieulafoy Lesion Of Stomach And Duodenum

Dieulafoy Disease

Exulceratio Simplex Dieulafoy

Dieulafoy'S Vascular Malformation
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12872 SHKBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SHKBP1 VGNC VGNC:46149
Mus musculus SHKBP1 MGD MGI:2385803
Rattus norvegicus SHKBP1 RGD RGD:1309281
Felis catus SHKBP1 VGNC VGNC:65126
Macaca mulatta SHKBP1 VGNC VGNC:77272
Bos taurus SHKBP1 VGNC VGNC:34602
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