2. Gene
  3. IGSF8 - immunoglobulin superfamily member 8 Gene

IGSF8 - immunoglobulin superfamily member 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：免疫球蛋白超家族成员 8

种属: Homo sapiens

同用名: EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1

基因 ID: 93185 | 基因类型: protein coding

关于 IGSF8

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,091,339-160,099,468 (from NCBI)

This gene has 5 transcripts (splice variants), 170 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues.

功能概要

该基因编码免疫球蛋白超家族的 EWI 亚家族成员。该家族的成员包含一个跨膜结构域、一个 EWI (Glu-Trp-Ile) -基序和数量可变的免疫球蛋白结构域。这种蛋白质与四跨膜蛋白 CD81 和 CD9 相互作用，并可能调节它们在某些细胞功能 (包括细胞迁移和病毒感染) 中的作用。所编码的蛋白质还可以通过抑制某些癌症的增殖而起到肿瘤抑制因子的作用。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral Infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

IGSF8 基因产物(3)

mRNA Protein Name
NM_001206665.2 NP_001193594.1 immunoglobulin superfamily member 8 precursor
NM_001320247.2 NP_001307176.1 immunoglobulin superfamily member 8 precursor
NM_052868.6 NP_443100.1 immunoglobulin superfamily member 8 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11504738 GOA
enables signaling receptor activity IDA
IDA: 通过直接分析推断
17785435 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
17785435 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
11504738 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IGSF8 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (36 - 141)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 613 a.a.
蛋白主名 其他名称

immunoglobulin superfamily member 8

CD81 partner 3

IGSF8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
种属内
IGSF8 Q969P0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
种属内
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
种属内
IGSF8 Q969P0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
种属内
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
种属内
IGSF8 Q969P0 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
种属内
IGSF8 Q969P0 TGM1 Homo sapiens P22735
Y2H Array
32296183
种属内
IGSF8 Q969P0 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IGSF8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72736 CD316/IGSF8 Protein, Human (HEK293, His) Q969P0-1 (R28-T579) ≥95%

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Atrial Septal Defect 2

ASD2

Atrial Heart Septal Defect 2

Atrial Septal Defect-2

Asd Ii

Septal Defect, Atrial, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06651 IGSF8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IGSF8 RGD RGD:1311500
Mus musculus IGSF8 MGD MGI:2154090
Canis familiaris IGSF8 VGNC VGNC:41918
Bos taurus IGSF8 VGNC VGNC:30096
Felis catus IGSF8 VGNC VGNC:62897
Macaca mulatta IGSF8 VGNC VGNC:73615
Others IGSF8 NCBI
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