2. Gene
  3. CER1 - cerberus 1, DAN family BMP antagonist Gene

CER1 - cerberus 1, DAN family BMP antagonist Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：cerberus 1，DAN 家族 BMP 拮抗因子

种属: Homo sapiens

同用名: DAND4

基因 ID: 9350 | 基因类型: protein coding

关于 CER1

Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:14,717,326-14,722,733 (from NCBI)

This gene has 1 transcript (splice variant), 125 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

该基因编码半胱氨酸结超家族的一个细胞因子成员，其特征是九个保守的半胱氨酸和一个半胱氨酸结区域。与 Cerberus 相关的细胞因子与 Dan 和 DRM/Gremlin 一起代表一组骨形态发生蛋白 (BMP) 拮抗剂，可以直接结合 BMP 并抑制其活性。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

CER1 基因产物(1)

mRNA Protein Name
NM_005454.3 NP_005445.1 cerberus precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP binding IDA
IDA: 通过直接分析推断
9660951 GOA
enables morphogen activity IDA
IDA: 通过直接分析推断
9660951 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone mineralization IMP
IMP: 通过突变表型推断
19113921 GOA
involved in determination of dorsal identity IMP
IMP: 通过突变表型推断
9660951 GOA
involved in negative regulation of activin receptor signaling pathway IDA
IDA: 通过直接分析推断
9660951 GOA
involved in negative regulation of mesoderm development IMP
IMP: 通过突变表型推断
9660951 GOA
involved in nervous system development IMP
IMP: 通过突变表型推断
9660951 GOA
involved in sequestering of BMP in extracellular matrix IDA
IDA: 通过直接分析推断
9660951 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CER1 蛋白结构

DAN

DAN: DAN domain (133 - 246)

  • 0
  • 100
  • 200
  • 267 a.a.
蛋白主名 其他名称

cerberus

DAN domain family member 4

重组 CER1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7822 Cerberus 1/CER1 Protein, Human (HEK293, His) AAI03977.1 (T18-A267) ≥95%
HY-P75350 Cerberus 1/CER1 Protein, Human (sf9, His) O95813 (M1-A267) ≥95%

关联疾病

疾病名称 别名
Chromosome 9p Deletion Syndrome

Monosomy 9p

Monosomy 9p Syndrome

Alfi Syndrome

9p Syndrome

Chromosome 9p Deletion

9p Deletion

9p Monosomy

Deletion 9p

Partial Monosomy 9p

9p Deletion Syndrome

9p- Syndrome

Alfi'S Syndrome

Chromosome 9, Partial Trisomy 9p
Cardiomyopathy, Dilated, 1x

Dilated Cardiomyopathy 1x

CMD1X

Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness

Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness

Cardiomyopathy, Dilated 1x

Cardiomyopathy, Dilated, Type 1x
Anisometropia
Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome

KLEFS1

Chromosome 9q34.3 Deletion Syndrome

9q- Syndrome

9q34 Deletion Syndrome

Kleefstra Syndrome Due To 9q34 Microdeletion

Kleefstra Syndrome

9q-Syndrome

9qstds

Kleefstra Syndrome Due To 9q Subtelomeric Deletion

Kleefstra Syndrome Due To Del(9)(Q34)

Kleefstra Syndrome Due To Monosomy 9q34

Chromosome 9q Subtelomeric Deletion Syndrome

Kleefstra Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126015 P053 Inhibitor ≥97.0% 否
HY-120803 Mefluidide / 否
HY-146910S CER1 (d18:1/26:0/18:1)-d9 / 否
HY-RS02532 CER1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02536 CERS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CER1 MGD MGI:1201414
Bos taurus CER1 VGNC VGNC:27221
Rattus norvegicus CER1 RGD RGD:1563046
Felis catus CER1 VGNC VGNC:102913
Macaca mulatta CER1 VGNC VGNC:71011
Canis familiaris CER1 VGNC VGNC:39145
Others CER1 NCBI
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