SLIT2 - slit guidance ligand 2 Gene

中文名称：狭缝引导配体 2

种属: Homo sapiens

同用名: SLIL3; Slit-2

基因 ID: 9353 | 基因类型: protein coding

关于 SLIT2

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:20,251,905-20,620,561 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 25 paralogues. Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues.

功能概要

该基因编码分泌糖蛋白 slit 家族的一个成员，该家族是免疫球蛋白受体 Robo 家族的配体。 Slit 蛋白在轴突导向和神经元迁移中发挥高度保守的作用，并且可能在其他细胞迁移过程 (包括白细胞迁移) 中发挥作用。狭缝家族成员的特征在于一个 N 末端信号肽、四个富含亮氨酸的重复序列、九个表皮生长因子重复序列和一个 C 末端半胱氨酸结。这种蛋白质的蛋白水解加工产生一个包含四个富含亮氨酸的重复序列和五个表皮生长因子重复序列的 N 末端片段，以及一个包含四个表皮生长因子重复序列和半胱氨酸结的 C 末端片段。全长和裂解蛋白都分泌到细胞外，可以在轴突排斥以及其他特定过程中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 9 月]

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during Other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as Other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

SLIT2 基因产物(3)

mRNA	Protein	Name
NM_001289135.3	NP_001276064.1	slit homolog 2 protein isoform 2 precursor
NM_001289136.3	NP_001276065.1	slit homolog 2 protein isoform 3 precursor
NM_004787.4	NP_004778.1	slit homolog 2 protein isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase inhibitor activity	IDA IDA: 通过直接分析推断	16439689	GOA
enables Roundabout binding	IPI IPI: 通过物理相互作用推断	10102268	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	17062560	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19498462	GOA
enables laminin-1 binding	IDA IDA: 通过直接分析推断	10102268	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10102268	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	19498462	GOA
enables proteoglycan binding	IPI IPI: 通过物理相互作用推断	11375980	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Roundabout signaling pathway	IMP IMP: 通过突变表型推断	18829537	GOA
involved in apoptotic process involved in luteolysis	IEP IEP: 通过表达模式推断	18566128	GOA
involved in axon extension involved in axon guidance	IDA IDA: 通过直接分析推断	16840550	GOA
involved in axon guidance	IDA IDA: 通过直接分析推断	11748139	GOA
involved in branching morphogenesis of an epithelial tube	IDA IDA: 通过直接分析推断	18345009	GOA
involved in branching morphogenesis of an epithelial tube	IMP IMP: 通过突变表型推断	19005219	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	19351956	GOA
involved in cellular response to heparin	IDA IDA: 通过直接分析推断	17062560	GOA
involved in cellular response to hormone stimulus	IEP IEP: 通过表达模式推断	18566128	GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA IDA: 通过直接分析推断	11748139	GOA
involved in chemorepulsion involved in postnatal olfactory bulb interneuron migration	IDA IDA: 通过直接分析推断	15207848	GOA
involved in corticospinal neuron axon guidance through spinal cord	IMP IMP: 通过突变表型推断	10975526	GOA
involved in induction of negative chemotaxis	IDA IDA: 通过直接分析推断	10197527	GOA
involved in motor neuron axon guidance	IDA IDA: 通过直接分析推断	10102268	GOA
involved in negative chemotaxis	IDA IDA: 通过直接分析推断	11748139	GOA
involved in negative chemotaxis	IMP IMP: 通过突变表型推断	19005219	GOA
involved in negative regulation of actin filament polymerization	IDA IDA: 通过直接分析推断	19759280	GOA
involved in negative regulation of cell growth	IMP IMP: 通过突变表型推断	18829537	GOA
involved in negative regulation of cell migration	IDA IDA: 通过直接分析推断	19005219	GOA
involved in negative regulation of cell migration	IMP IMP: 通过突变表型推断	18566128	GOA
involved in negative regulation of cellular response to growth factor stimulus	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of chemokine-mediated signaling pathway	IMP IMP: 通过突变表型推断	18829537	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: 通过直接分析推断	18345009	GOA
involved in negative regulation of lamellipodium assembly	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of leukocyte chemotaxis	IDA IDA: 通过直接分析推断	11309622	GOA
involved in negative regulation of mononuclear cell migration	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of neutrophil chemotaxis	IDA IDA: 通过直接分析推断	19759280	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	18345009	GOA
involved in negative regulation of retinal ganglion cell axon guidance	IDA IDA: 通过直接分析推断	17062560	GOA
involved in negative regulation of small GTPase mediated signal transduction	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of smooth muscle cell chemotaxis	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of smooth muscle cell migration	IDA IDA: 通过直接分析推断	16439689	GOA
involved in negative regulation of vascular permeability	IDA IDA: 通过直接分析推断	18345009	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	18566128	GOA
involved in response to cortisol	IEP IEP: 通过表达模式推断	18566128	GOA
involved in retinal ganglion cell axon guidance	IDA IDA: 通过直接分析推断	10864954	GOA
involved in ureteric bud development	IMP IMP: 通过突变表型推断	15130495	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	10102268	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18566128	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	10102268	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLIT2 蛋白结构

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_1

LRR_8

LRRCT

EGF

Laminin_G_1

0
300
600
900
1200
1529 a.a.

蛋白主名

其他名称

slit homolog 2 protein

SLIT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLIT2	O94813	SLIT2	Homo sapiens	O94813	DLS	19498462
种属内	SLIT2	O94813	SLIT2	Homo sapiens	O94813	X-Ray Diffraction	19498462
种属内	SLIT2	O94813	ROBO1	Homo sapiens	Q9Y6N7	SPR	17848514
种属内	SLIT2	O94813	a0a2u2h391_yerpe	Yersinia pestis	A0A2U2H391	Y2H Pooling	20711500
种属内	SLIT2	O94813	HOXA1	Homo sapiens	P49639	Y2H Pooling	21653829
种属内	SLIT2	O94813	ROBO1	Homo sapiens	Q9Y6N7	X-Ray Diffraction	17848514
种属内	SLIT2	O94813	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H	18985028
种属内	SLIT2	O94813	Q9WMX2-PRO_0000037546	Hepatitis C virus	Q9WMX2-PRO_0000037546	Y2H	18985028
种属内	SLIT2	O94813	bilf1_ebvb9	Epstein-Barr virus	P03208	Y2H	17446270

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-146411	microRNA-21-IN-1		98.03%	否
HY-RS13371	SLIT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SLIT2	VGNC	VGNC:77644
Mus musculus	SLIT2	MGD	MGI:1315205
Bos taurus	SLIT2	VGNC	VGNC:34960
Rattus norvegicus	SLIT2	RGD	RGD:69310
Canis familiaris	SLIT2	VGNC	VGNC:46504

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLIT2 - slit guidance ligand 2 Gene

关于 SLIT2

功能概要

SLIT2 基因产物(3)

SLIT2 蛋白结构

SLIT2 蛋白互作信息

关联疾病

直系同源

热门区域

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SLIT2 - slit guidance ligand 2 Gene

关于 SLIT2

功能概要

SLIT2 基因产物(3)

SLIT2 蛋白结构

SLIT2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z