ABCC12 - ATP binding cassette subfamily C member 12 Gene

中文名称：ATP 结合盒亚家族 C 成员 12

种属: Homo sapiens

同用名: MRP9

基因 ID: 94160 | 基因类型: protein coding

关于 ABCC12

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:48,080,882-48,155,993 (from NCBI)

This gene has 14 transcripts (splice variants), 224 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 3.1).

功能概要

该基因是 ATP 结合盒 (ABC) 转运蛋白超家族的成员，编码的蛋白质包含两个 ATP 结合域和 12 个跨膜区域。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族：ABC1、MDR/TAP、MRP、ALD、OABP、GCN20 和 White。该基因是参与多药耐药性的 MRP 亚家族的成员。该基因和另一个亚科成员在染色体 16q12.1 上首尾相连。该基因表达增加与乳腺癌有关。[RefSeq 提供，2008 年 7 月]

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast Cancer. [provided by RefSeq, Jul 2008]

ABCC12 基因产物(5)

mRNA	Protein	Name
NM_001392028.1	NP_001378957.1	ATP-binding cassette sub-family C member 12 isoform 2
NM_001393797.1	NP_001380726.1	ATP-binding cassette sub-family C member 12 isoform 3
NM_001393798.1	NP_001380727.1	ATP-binding cassette sub-family C member 12 isoform 4
NM_001393799.1	NP_001380728.1	ATP-binding cassette sub-family C member 12 isoform 5
NM_033226.3	NP_150229.2	ATP-binding cassette sub-family C member 12 isoform 1

基因本体论

细胞组分

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	17472575	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABCC12 蛋白结构

ABC_membrane

ABC_tran

ABC_membrane

ABC_tran

0
300
600
900
1200
1359 a.a.

蛋白主名

其他名称

ATP-binding cassette sub-family C member 12

ATP-binding cassette transporter sub-family C member 12

关联疾病

疾病名称

别名

Episodic Kinesigenic Dyskinesia 1

Paroxysmal Kinesigenic Choreoathetosis	Paroxysmal Kinesigenic Dyskinesia
Dystonia 10	Familial Paroxysmal Kinesigenic Dyskinesia
Episodic Kinesigenic Dyskinesia	EKD1
Pkc	Pkd
Dyt10	Familial Pkd
Paroxysmal Kinesigenic Choreathetosis	Familial Paroxysmal Dystonia
Dystonia, Familial Paroxysmal	Dyt-Prrt2
Dystonia, Type 10

Dubin-Johnson Syndrome

DJS	Chronic Idiopathic Jaundice
Jaundice, Chronic Idiopathic	Hyperbilirubinemia, Dubin-Johnson Type
Hyperbilirubinemia Ii	Hyperbilirubinemia Type 2
Conjugated Hyperbilirubinemia	Dubin-Sprinz Disease
Sprinz-Nelson Syndrome	Hblrdj
Dubin Johnson Syndrome	Hyperbilirubinemia 2
Black Liver-Jaundice Syndrome	Chronic Idiopathic Jaundice With Pigmented Liver
Dubin-Sprinz Syndrome	Hyperbilirubinaemia Type 2
Djs - [Dubin-Johnson Syndrome]

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00060	ABCC12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ABCC12	VGNC	VGNC:59470
Mus musculus	ABCC12	MGD	MGI:2441679
Bos taurus	ABCC12	VGNC	VGNC:25471
Macaca mulatta	ABCC12	VGNC	VGNC:69404
Rattus norvegicus	ABCC12	RGD	RGD:735100
Canis familiaris	ABCC12	VGNC	VGNC:37439

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ABCC12 - ATP binding cassette subfamily C member 12 Gene

关于 ABCC12

功能概要

ABCC12 基因产物(5)

ABCC12 蛋白结构

关联疾病

直系同源

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ABCC12 - ATP binding cassette subfamily C member 12 Gene

关于 ABCC12

功能概要

ABCC12 基因产物(5)

ABCC12 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z