MED23 - mediator complex subunit 23 Gene

中文名称：介体复合体亚基 23

种属: Homo sapiens

同用名: SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130

基因 ID: 9439 | 基因类型: protein coding

关于 MED23

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,573,966-131,628,313 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 8.5) and 25 other tissues.

功能概要

基因转录的激活是一个多步骤过程，由识别 DNA 中转录增强子位点的因素触发。这些因子与共激活因子一起通过 RNA 聚合酶 II 装置指导转录起始。该基因编码的蛋白质是 CRSP (SP1 激活所需的辅因子) 复合物的一个亚基，它与 TFIID 一起是 SP1 有效激活所必需的。这种蛋白质也是其他多亚基复合物的组成部分，例如甲状腺激素受体- (TR-) 相关蛋白，它与 TR 相互作用并促进 TR 在 DNA 模板上与起始因子和辅因子一起发挥功能。这种蛋白质还充当转移抑制因子。已经针对该基因描述了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

MED23 基因产物(12)

mRNA	Protein	Name
NM_001270521.2	NP_001257450.1	mediator of RNA polymerase II transcription subunit 23 isoform c
NM_001270522.2	NP_001257451.1	mediator of RNA polymerase II transcription subunit 23 isoform d
NM_001376517.1	NP_001363446.1	mediator of RNA polymerase II transcription subunit 23 isoform e
NM_001376518.1	NP_001363447.1	mediator of RNA polymerase II transcription subunit 23 isoform f
NM_001376519.1	NP_001363448.1	mediator of RNA polymerase II transcription subunit 23 isoform g
NM_001376520.1	NP_001363449.1	mediator of RNA polymerase II transcription subunit 23 isoform h
NM_001376521.1	NP_001363450.1	mediator of RNA polymerase II transcription subunit 23 isoform i
NM_001376522.1	NP_001363451.1	mediator of RNA polymerase II transcription subunit 23 isoform j
NM_001376523.1	NP_001363452.1	mediator of RNA polymerase II transcription subunit 23 isoform k
NM_001376524.1	NP_001363453.1	mediator of RNA polymerase II transcription subunit 23 isoform l
NM_004830.4	NP_004821.2	mediator of RNA polymerase II transcription subunit 23 isoform a
NM_015979.4	NP_057063.2	mediator of RNA polymerase II transcription subunit 23 isoform b

MED23 蛋白结构

Med23

0
300
600
900
1200
1368 a.a.

蛋白主名

其他名称

mediator of RNA polymerase II transcription subunit 23

130 kDa transcriptional co-activator

MED23 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Y2H	12421765
种属内	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Anti Tag CoIP	33961781
种属内	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	BioID	25281560
种属内	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
种属内	MED23	Q9ULK4	MED14	Homo sapiens	O60244	BioID	25281560
种属内	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Pull Down	25281560
种属内	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	33961781
种属内	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	BioID	25281560
种属内	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Pull Down	25281560
种属内	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	33961781
种属内	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	33961781
种属内	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	BioID	25281560
种属内	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Pull Down	25281560

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Recessive 18, With Or Without Epilepsy

Intellectual Developmental Disorder, Autosomal Recessive 18	MRT18
Mental Retardation, Autosomal Recessive 18	Autosomal Recessive Intellectual Developmental Disorder 18
Mental Retardation, Autosomal Recessive, Type 18

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Argininemia

Hyperargininemia	Arginase Deficiency
Arg1 Deficiency	Arginase-1 Deficiency
Deficiency Of Canavanase	Arginase Deficiency Disease
ARGIN

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

Methylcobalamin Deficiency, Cblg Type	HMAG
Methionine Synthase Deficiency	Methylcobalamin Deficiency Type Cblg
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type	Homocystinuria-Megaloblastic Anemia Cblg Type
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type	Methylcobalamin Deficiency Cbl G Type
Homocystinuria Due To Defect In Methylation Cbl G	Cblg
Functional Methionine Synthase Deficiency Type Cblg	Methylcobalamin Deficiency Cblg Type
Arakawa Syndrome 2

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-158005	Anticancer agent 195	Inducer	/	否
HY-RS08294	MED23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MED23	VGNC	VGNC:43131
Bos taurus	MED23	VGNC	VGNC:31360
Mus musculus	MED23	MGD	MGI:1917458
Rattus norvegicus	MED23	RGD	RGD:1307671
Macaca mulatta	MED23	VGNC	VGNC:74562
Felis catus	MED23	VGNC	VGNC:102459

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MED23 - mediator complex subunit 23 Gene

关于 MED23

功能概要

MED23 基因产物(12)

MED23 蛋白结构

MED23 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MED23 - mediator complex subunit 23 Gene

关于 MED23

功能概要

MED23 基因产物(12)

MED23 蛋白结构

MED23 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z