MED14 - mediator complex subunit 14 Gene

中文名称：调解复合体亚基 14

种属: Homo sapiens

同用名: CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170

关于 MED14

功能概要

基因转录的激活是一个多步骤过程，由识别 DNA 中转录增强子位点的因素触发。这些因子与共激活因子一起通过 RNA 聚合酶 II 装置指导转录起始。该基因编码的蛋白质是 CRSP (SP1 激活所需的辅因子) 复合物的一个亚基，它与 TFIID 一起是 SP1 有效激活所必需的。这种蛋白质也是其他多亚基复合物的组成部分，例如甲状腺激素受体- (TR-) 相关蛋白，它与 TR 相互作用并促进 TR 在 DNA 模板上与起始因子和辅因子一起发挥功能。该蛋白质包含二分核定位信号。已知该基因可以逃避染色体 X 失活。[RefSeq 提供，2008 年 7 月]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]