1. Gene
  2. MED24 - mediator complex subunit 24 Gene

MED24 - mediator complex subunit 24 Gene

中文名称:介体复合体亚基 24

种属: Homo sapiens

同用名: MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100

基因 ID: 9862 | 基因类型: protein coding

关于 MED24

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,019,104-40,054,408 (from NCBI)

This gene has 33 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 18.9), brain (RPKM 13.4) and 25 other tissues.

功能概要

该基因编码介体复合体 (也称为 TRAP、SMCC、DRIP 或 ARC) 的一个组分,这是一种转录共激活因子复合体,被认为是几乎所有基因表达所必需的。介体复合物由转录激活因子或核受体募集以诱导基因表达,可能通过与 RNA 聚合酶 II 相互作用并促进转录前起始复合物的形成。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MED24 基因产物(4)

mRNA Protein Name
NM_001079518.2 NP_001072986.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001267797.2 NP_001254726.1 mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001330211.2 NP_001317140.1 mediator of RNA polymerase II transcription subunit 24 isoform 3
NM_014815.4 NP_055630.2 mediator of RNA polymerase II transcription subunit 24 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear thyroid hormone receptor binding IDA
IDA: 通过直接分析推断
10198638 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24882805 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
12218053 GOA
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
10198638 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10198638 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: 通过直接分析推断
12218053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of core mediator complex IPI
IPI: 通过物理相互作用推断
24882805 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10235267 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MED24 蛋白结构

Med24_N

Med24_N: Mediator complex subunit 24 N-terminal (1 - 987)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 989 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 24

CRSP complex subunit 4

MED24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MED24 O75448 MED14 Homo sapiens O60244 33961781
种属内
MED24 O75448 MED16 Homo sapiens Q9Y2X0 33961781
种属内
MED24 O75448 MED25 Homo sapiens Q71SY5 33961781
种属内
MED24 O75448 MED25 Homo sapiens Q71SY5 24882805
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MED24 RGD RGD:1564565
Bos taurus MED24 VGNC VGNC:31361
Felis catus MED24 VGNC VGNC:63438
Mus musculus MED24 MGD MGI:1344385
Canis familiaris MED24 VGNC VGNC:43132