MED15 - mediator complex subunit 15 Gene

中文名称：介体复合物亚基 15

种属: Homo sapiens

同用名: TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105

基因 ID: 51586 | 基因类型: protein coding

关于 MED15

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,507,610-20,587,619 (from NCBI)

This gene has 31 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是多蛋白复合物 PC2 和 ARC/DRIP 的一个亚基，可能在 RNA 聚合酶 II 转录中起转录共激活因子的作用。该基因包含一段三核苷酸重复序列，位于 22 号染色体区域，该区域在 DiGeorge 综合征中缺失。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 6 月]

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

MED15 基因产物(6)

mRNA	Protein	Name
NM_001003891.3	NP_001003891.1	mediator of RNA polymerase II transcription subunit 15 isoform a
NM_001293234.2	NP_001280163.1	mediator of RNA polymerase II transcription subunit 15 isoform c
NM_001293235.2	NP_001280164.1	mediator of RNA polymerase II transcription subunit 15 isoform d
NM_001293236.2	NP_001280165.1	mediator of RNA polymerase II transcription subunit 15 isoform e
NM_001293237.2	NP_001280166.1	mediator of RNA polymerase II transcription subunit 15 isoform d
NM_015889.5	NP_056973.2	mediator of RNA polymerase II transcription subunit 15 isoform b

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16799563	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of core mediator complex	IPI IPI: 通过物理相互作用推断	24882805	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24882805	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MED15 蛋白结构

Med15

0
200
400
600
788 a.a.

蛋白主名

其他名称

mediator of RNA polymerase II transcription subunit 15

CTG repeat protein 7a

MED15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MED15	Q96RN5	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
种属内	MED15	Q96RN5	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	24882805
种属内	MED15	Q96RN5	SREBF2	Homo sapiens	Q12772	Pull Down	16799563
种属内	MED15	Q96RN5	HTT	Homo sapiens	P42858	Y2H	17500595
种属内	MED15	Q96RN5	TRIM11	Homo sapiens	Q96F44	Imaging	16904669
种属内	MED15	Q96RN5	TRIM11	Homo sapiens	Q96F44	Anti Tag CoIP	16904669
种属内	MED15	Q96RN5	SREBF1	Homo sapiens	P36956-1	Pull Down	18385733
种属内	MED15	Q96RN5	SREBF1	Homo sapiens	P36956-3	Pull Down	16799563

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Ureterocele

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08286	MED15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MED15	VGNC	VGNC:74511
Rattus norvegicus	MED15	RGD	RGD:1307560
Canis familiaris	MED15	VGNC	VGNC:43125
Mus musculus	MED15	MGD	MGI:2137379
Bos taurus	MED15	VGNC	VGNC:31353

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MED15 - mediator complex subunit 15 Gene

关于 MED15

功能概要

MED15 基因产物(6)

MED15 蛋白结构

MED15 蛋白互作信息

关联疾病

直系同源

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MED15 - mediator complex subunit 15 Gene

关于 MED15

功能概要

MED15 基因产物(6)

MED15 蛋白结构

MED15 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

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J

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Q

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