IL27RA - interleukin 27 receptor subunit alpha Gene

中文名称：白介素 27 受体亚基 α

种属: Homo sapiens

同用名: CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1

关于 IL27RA

功能概要

在小鼠中，CD4+ 辅助性 T 细胞分化为 1 型 (Th1) 细胞，这对细胞介导的免疫至关重要，主要受 IL12 的影响。此外，IL4 影响它们分化为 2 型 (Th2) 细胞，这对大多数抗体反应至关重要。缺乏这些细胞因子、它们的受体或相关转录因子的小鼠已经受损，但并非没有 Th1 或 Th2 免疫反应。该基因编码的蛋白质在氨基酸水平上与小鼠 T 细胞细胞因子受体 Tccr 相似，预计为糖基化跨膜蛋白。[RefSeq 提供，2008 年 7 月]

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]