2. Gene
  3. DERL3 - derlin 3 Gene

DERL3 - derlin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：德林 3

种属: Homo sapiens

同用名: IZP6; LLN2; C22orf14; derlin-3

基因 ID: 91319 | 基因类型: protein coding

关于 DERL3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,834,503-23,839,006 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 176 orthologues and 2 paralogues. Broad expression in stomach (RPKM 12.2), duodenum (RPKM 11.1) and 22 other tissues.

功能概要

由该基因编码的蛋白质属于 derlin 家族，位于内质网 (ER) 中。在 ER 中展开或错误折叠的蛋白质必须重新折叠或降解以维持 ER 的稳态。这种蛋白质似乎参与了 ER 中错误折叠的糖蛋白的降解。已经为该基因鉴定了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

DERL3 基因产物(4)

mRNA Protein Name
NM_001002862.3 NP_001002862.1 derlin-3 isoform 2
NM_001135751.2 NP_001129223.1 derlin-3 isoform 1
NM_001363072.2 NP_001350001.1 derlin-3 isoform 4
NM_198440.4 NP_940842.2 derlin-3 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16449189 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
26565908 GOA
enables signal recognition particle binding IDA
IDA: 通过直接分析推断
26565908 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
22607976 GOA
involved in endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
16449189 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: 通过突变表型推断
25660456 GOA
involved in protein N-linked glycosylation via asparagine IMP
IMP: 通过突变表型推断
22607976 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
16449189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DERL3 蛋白结构

DER1

DER1: Der1-like family (13 - 202)

  • 0
  • 100
  • 200
  • 235 a.a.
蛋白主名 其他名称

derlin-3

DERtrin 3

DERL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DERL3 Q96Q80 TMEM92 Homo sapiens Q6UXU6
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 TMEM92 Homo sapiens Q6UXU6
Y2H Array
32296183
Intra DERL3 Q96Q80 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra DERL3 Q96Q80 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra DERL3 Q96Q80 RTP4 Homo sapiens Q96DX8
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 RTP4 Homo sapiens Q96DX8
Y2H Array
32296183
Intra DERL3 Q96Q80 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra DERL3 Q96Q80 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra DERL3 Q96Q80 GNLY Homo sapiens P22749
Y2H Array
32296183
Intra DERL3 Q96Q80 GNLY Homo sapiens P22749
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra DERL3 Q96Q80 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
Intra DERL3 Q96Q80 IL27RA Homo sapiens Q6UWB1
Y2H Array
32296183
Intra DERL3 Q96Q80 IL27RA Homo sapiens Q6UWB1
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 EHHADH Homo sapiens Q08426
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 ULBP2 Homo sapiens Q9BZM5
Y2H Prey Pooling
32296183
Intra DERL3 Q96Q80 ULBP2 Homo sapiens Q9BZM5
Validated Y2H
32296183
Intra DERL3 Q96Q80 ULBP2 Homo sapiens Q9BZM5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03701 DERL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-169003 STT3A/B-IN-1 / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DERL3 VGNC VGNC:71622
Mus musculus DERL3 MGD MGI:1917627
Rattus norvegicus DERL3 RGD RGD:1597373
Bos taurus DERL3 VGNC VGNC:28012
Felis catus DERL3 VGNC VGNC:61450
Canis familiaris DERL3 VGNC VGNC:39904
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