GNLY - granulysin Gene

中文名称：颗粒溶素

种属: Homo sapiens

同用名: LAG2; NKG5; LAG-2; D2S69E; TLA519

基因 ID: 10578 | 基因类型: protein coding

关于 GNLY

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,694,358-85,698,852 (from NCBI)

This gene has 14 transcripts (splice variants) and 50 orthologues. Biased expression in bone marrow (RPKM 67.6), endometrium (RPKM 42.4) and 5 other tissues.

功能概要

该基因的产物是类皂苷蛋白 (SAPLIP) 家族的成员，位于 T 细胞的细胞毒性颗粒中，在抗原刺激时释放。这种蛋白质存在于细胞毒性 T 淋巴细胞和自然杀伤细胞的细胞毒性颗粒中，对结核分枝杆菌和其他生物体具有抗菌活性。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GNLY 基因产物(3)

mRNA	Protein	Name
NM_001302758.2	NP_001289687.1	granulysin isoform 1 precursor
NM_006433.5	NP_006424.2	granulysin isoform 2 precursor
NM_012483.4	NP_036615.2	granulysin isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	9756476	GOA
involved in cellular defense response	IDA IDA: 通过直接分析推断	9756476	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	9756476	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	9756476	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with cytolytic granule	IDA IDA: 通过直接分析推断	9756476	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNLY 蛋白结构

SapB_2

0
100
145 a.a.

蛋白主名

其他名称

granulysin

T-cell activation protein 519

GNLY 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	GNLY	P22749	DERL3	Homo sapiens	Q96Q80	Validated Y2H	32296183
Intra	GNLY	P22749	BCL2L1	Homo sapiens	Q07817	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Erythema Multiforme

Dermatostomatitis, Erythema Multiforme Type	Em
Erythema Multiforme Bullosum	Erythema Polymorphe, Erythema Multiforme Type
Febrile Mucocutaneous Syndrome	Herpes Iris, Erythema Multiforme Type
Stevens-Johnson Syndrome	Em - [Erythema Multiforme]

Kyphoscoliotic Heart Disease

Folliculitis

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Phenytoin Allergy

Dilantin Allergy

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil	Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Casil	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Familial Vascular Leukoencephalopathy	CADASIL1
Cadasil 1	Hereditary Multi-Infarct Dementia
Cadasil Syndrome	Dementia, Hereditary Multiinfarct Type
Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1	Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy	Dementia, Hereditary Multi-Infarct Type
Hereditary Dementia, Multi-Infarct Type	Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant
Dementia Hereditary Multiinfarct Type	Dementia Hereditary Multi-Infarct Type
Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Tick Paralysis

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-110266	GN44028	Inhibitor	99.48%	否
HY-117280	GN25	Activator	98.81%	否
HY-163338	Metallo-β-lactamase-IN-13	Inhibitor	/	否
HY-163339	Metallo-β-lactamase-IN-14	Inhibitor	/	否
HY-RS05568	GNLY Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

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GNLY - granulysin Gene

关于 GNLY

功能概要

GNLY 基因产物(3)

GNLY 蛋白结构

GNLY 蛋白互作信息

关联疾病

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GNLY - granulysin Gene

关于 GNLY

功能概要

GNLY 基因产物(3)

GNLY 蛋白结构

GNLY 蛋白互作信息

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

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