2. Gene
  3. TMEM59 - transmembrane protein 59 Gene

TMEM59 - transmembrane protein 59 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 59

种属: Homo sapiens

同用名: DCF1; C1orf8; PRO195; UNQ169; HSPC001

基因 ID: 9528 | 基因类型: protein coding

关于 TMEM59

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:54,026,681-54,053,573 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 47.8), prostate (RPKM 39.1) and 25 other tissues.

功能概要

该基因编码一种蛋白质，可调节自噬以应对细菌感染。该蛋白质还可以通过控制 APP 糖基化来调节淀粉样前体蛋白 (APP) 在高尔基体中的保留。已发现该蛋白的过度表达可促进神经胶质瘤细胞系的细胞凋亡。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 2 月]

This gene encodes a protein shown to regulate Autophagy in response to Bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote Apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEM59 基因产物(7)

mRNA Protein Name
NM_001305043.2 NP_001291972.1 transmembrane protein 59 isoform 1 precursor
NM_001305049.1 NP_001291978.1 transmembrane protein 59 isoform 3 precursor
NM_001305050.2 NP_001291979.1 transmembrane protein 59 isoform 4 precursor
NM_001305051.1 NP_001291980.1 transmembrane protein 59 isoform 6 precursor
NM_001305052.1 NP_001291981.1 transmembrane protein 59 isoform 6 precursor
NM_001305066.2 NP_001291995.1 transmembrane protein 59 isoform 5 precursor
NM_004872.5 NP_004863.2 transmembrane protein 59 isoform 2 precursor

TMEM59 蛋白结构

BSMAP

BSMAP: Brain specific membrane anchored protein (72 - 256)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

transmembrane protein 59

dendritic cell factor 1

TMEM59 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMEM59 Q9BXS4 ATG16L1 Homo sapiens Q676U5
Pull Down
23376921
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Estrogen Resistance

Estrogen Resistance Syndrome

ESTRR

Estrogen Insensitivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14731 TMEM59 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMEM59 VGNC VGNC:47590
Rattus norvegicus TMEM59 RGD RGD:1310313
Macaca mulatta TMEM59 VGNC VGNC:78665
Mus musculus TMEM59 MGD MGI:1929278
Bos taurus TMEM59 VGNC VGNC:36099
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