CREB5 - cAMP responsive element binding protein 5 Gene

中文名称：cAMP 反应元件结合蛋白 5

种属: Homo sapiens

同用名: CREB-5; CREBPA; CRE-BPA

基因 ID: 9586 | 基因类型: protein coding

关于 CREB5

Cytogenetic location: 7p15.1-p14.3 Genomic coordinates (GRCh38): 7:28,299,321-28,825,894 (from NCBI)

This gene has 15 transcripts (splice variants), 245 orthologues and 2 paralogues. Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues.

功能概要

该基因的产物属于 CRE (cAMP 反应元件) 结合蛋白家族。该家族的成员包含锌指和 bZIP DNA 结合域。编码的蛋白质作为同二聚体或异二聚体与 c-Jun 或 CRE-BP1 特异性结合 CRE，并作为 CRE 依赖性反式激活剂发挥作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CREB5 基因产物(4)

mRNA	Protein	Name
NM_001011666.3	NP_001011666.1	cyclic AMP-responsive element-binding protein 5 isoform delta
NM_004904.4	NP_004895.2	cyclic AMP-responsive element-binding protein 5 isoform beta
NM_182898.4	NP_878901.2	cyclic AMP-responsive element-binding protein 5 isoform alpha
NM_182899.5	NP_878902.2	cyclic AMP-responsive element-binding protein 5 isoform gamma

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	8378084	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8440710	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	8378084	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CREB5 蛋白结构

bZIP_1

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

cyclic AMP-responsive element-binding protein 5

cAMP response element-binding protein CRE-BPa

关联疾病

疾病名称

别名

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Achalasia

Cardiospasm	Achalasia Of Cardia
Esophageal Achalasia	Hypertensive Lower Esophageal Sphincter
Idiopathic Achalasia	Achalasia Cardia
Idiopathic Achalasia Of Esophagus	Primary Achalasia
Achalasia Of Esophagus	Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter
Aperistalsis Of The Oesophagus	Achalasia Of Oesophagus
Oesophageal Achalasia	Achalasia Nos
Cardia Spasm	Cardia Achalasia
Oesophageal Cardiospasm	Oesophagus Achalasia
Reflex Cardiospasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03154	CREB5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CREB5	VGNC	VGNC:39600
Felis catus	CREB5	VGNC	VGNC:61170
Mus musculus	CREB5	MGD	MGI:2443973
Rattus norvegicus	CREB5	RGD	RGD:1566107
Macaca mulatta	CREB5	VGNC	VGNC:81295
Bos taurus	CREB5	VGNC	VGNC:106699

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