2. Gene
  3. CARTPT - CART prepropeptide Gene

CARTPT - CART prepropeptide Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CART 前肽原

种属: Homo sapiens

同用名: CART

基因 ID: 9607 | 基因类型: protein coding

关于 CARTPT

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:71,719,275-71,721,045 (from NCBI)

This gene has 2 transcripts (splice variants), 270 orthologues and is associated with 1 phenotype. Biased expression in adrenal (RPKM 51.3), brain (RPKM 5.7) and 1 other tissue.

功能概要

该基因编码一种前原蛋白，该蛋白经过蛋白水解处理可产生多种生物活性肽。这些肽在食欲、能量平衡、维持体重、奖励和成瘾以及应激反应中发挥作用。在施用可卡因和苯丙胺后，啮齿动物中相似基因转录物的表达上调。该基因的突变与人类对肥胖的易感性有关。[RefSeq 提供，2016 年 2 月]

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active Peptides. These Peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

CARTPT 基因产物(1)

mRNA Protein Name
NM_004291.4 NP_004282.1 cocaine- and amphetamine-regulated transcript protein preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21982860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular glucose homeostasis IDA
IDA: 通过直接分析推断
11711504 GOA
involved in negative regulation of bone resorption IMP
IMP: 通过突变表型推断
16614075 GOA
involved in positive regulation of blood pressure IDA
IDA: 通过直接分析推断
11711504 GOA
involved in positive regulation of epinephrine secretion IDA
IDA: 通过直接分析推断
11711504 GOA
involved in positive regulation of transmission of nerve impulse IDA
IDA: 通过直接分析推断
11711504 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11711504 GOA
located in secretory granule IDA
IDA: 通过直接分析推断
21624661 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARTPT 蛋白结构

CART

CART: Cocaine and amphetamine regulated transcript protein (CART) (45 - 116)

  • 0
  • 100
  • 116 a.a.
蛋白主名 其他名称

cocaine- and amphetamine-regulated transcript protein

重组 CARTPT 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74350 CART Protein, Human (HEK293, Fc) Q16568 (Q28-L116) ≥95%
HY-P74351 CART Protein, Human (HEK293) Q16568/NP_004282.1 (Q28-L116) ≥95%

关联疾病

疾病名称 别名
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Leptin

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01935 CARTPT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CARTPT VGNC VGNC:60375
Macaca mulatta CARTPT VGNC VGNC:70619
Rattus norvegicus CARTPT RGD RGD:2272
Mus musculus CARTPT MGD MGI:1351330
Bos taurus CARTPT VGNC VGNC:26774
Canis familiaris CARTPT VGNC VGNC:38727
Others CARTPT NCBI
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