1. Gene
  2. TESMIN - testis expressed metallothionein like protein Gene

TESMIN - testis expressed metallothionein like protein Gene

中文名称:睾丸表达金属硫蛋白样蛋白

种属: Homo sapiens

同用名: MTL5; MTLT; CXCDC2

基因 ID: 9633 | 基因类型: protein coding

关于 TESMIN

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:68,704,796-68,751,520 (from NCBI)

This gene has 9 transcripts (splice variants), 129 orthologues and 1 paralogue. Biased expression in testis (RPKM 13.9), bone marrow (RPKM 1.4) and 2 other tissues.

功能概要

金属硫蛋白是高度保守的低分子量富含半胱氨酸的蛋白质,由重金属离子诱导并与之结合,没有酶活性。它们可能在细胞生长和分化的调节中发挥核心作用,并参与精子发生。该基因编码一种金属硫蛋白样蛋白,该蛋白已被证明在小鼠睾丸和卵巢中有差异表达。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2008 年 7 月]

Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TESMIN 基因产物(2)

mRNA Protein Name
NM_001039656.1 NP_001034745.1 tesmin isoform b
NM_004923.3 NP_004914.2 tesmin isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TESMIN 蛋白结构

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (306 - 330)

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (365 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

tesmin

CXC domain containing 2

关联疾病

疾病名称 别名
Childhood B-Cell Acute Lymphoblastic Leukemia

B-Cell Childhood Acute Lymphoblastic Leukemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TESMIN VGNC VGNC:68342
Macaca mulatta TESMIN VGNC VGNC:79965
Rattus norvegicus TESMIN RGD RGD:1309788
Mus musculus TESMIN MGD MGI:1340029
Canis familiaris TESMIN VGNC VGNC:47258
Bos taurus TESMIN VGNC VGNC:106972