2. Gene
  3. EIF5B - eukaryotic translation initiation factor 5B Gene

EIF5B - eukaryotic translation initiation factor 5B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 5B

种属: Homo sapiens

同用名: IF2

基因 ID: 9669 | 基因类型: protein coding

关于 EIF5B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,337,389-99,401,326 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues and 18 paralogues. Ubiquitous expression in heart (RPKM 26.2), testis (RPKM 23.3) and 25 other tissues.

功能概要

在真核生物中准确启动翻译是复杂的，需要许多因素，其中一些因素由多个亚基组成。该过程在只有三个起始因子 (IF1、IF2、IF3) 的原核生物中更简单。其中两个因子在真核生物中是保守的：IF1 的同系物是 eIF1A，IF2 的同系物是 eIF5B。该基因编码 eIF5B。因子 eIF1A 和 eIF5B 与其他起始因子和 GTP 在核糖体上相互作用，将起始甲硫氨酸 tRNA 定位在 mRNA 的起始密码子上，从而准确地启动翻译。[RefSeq 提供，2008 年 7 月]

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with Other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

EIF5B 基因产物(1)

mRNA Protein Name
NM_015904.4 NP_056988.3 eukaryotic translation initiation factor 5B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
10659855 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
10659855 GOA
enables GTPase activity IMP
IMP: 通过突变表型推断
35732735 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12569173 GOA
enables tRNA binding IDA
IDA: 通过直接分析推断
35732735 GOA
enables translation initiation factor activity IDA
IDA: 通过直接分析推断
10432305 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of translational initiation IDA
IDA: 通过直接分析推断
10432305 GOA
involved in ribosome assembly IDA
IDA: 通过直接分析推断
10659855 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12426392 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
12426392 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF5B 蛋白结构

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (632 - 842)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (870 - 944)

IF-2

IF-2: Translation-initiation factor 2 (965 - 1070)

GTP_EFTU_D4

GTP_EFTU_D4: Elongation factor Tu domain 4 (1091 - 1162)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1220 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 5B

eIF-5B

EIF5B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
EIF5B O60841 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
EIF5B O60841 GRN Homo sapiens P28799
Validated Y2H
32814053
种属内
EIF5B O60841 GRN Homo sapiens P28799
Y2H Pooling
32814053
种属内
EIF5B O60841 GRN Homo sapiens P28799
Y2H Array
32814053
种属内
EIF5B O60841 ETS1 Homo sapiens P14921
TAP
20195357
种属内
EIF5B O60841 ETS1 Homo sapiens P14921
Display Tech
20195357
种属内
EIF5B O60841 PEX1 Homo sapiens O43933
Validated Y2H
32814053
种属内
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属内
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Liposarcoma
Acquired Color Blindness

Acquired Color Vision Deficiencies

Acquired Color Vision Deficiency

Acquired Colour Blindness

Acquired Colour Vision Deficiencies

Acquired Colour Vision Deficiency
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Primary Polycythemia

Familial Erythrocytosis

Familiar Polycythemia

Benign Familial Polycythemia

Congenital Erythrocytosis

Familial Polycythemia

Hereditary Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Familial

Polycythemia Vera

Primary Familial Polycythaemia

Primary Inherited Polycythaemia
Parameningeal Embryonal Rhabdomyosarcoma
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04288 EIF5B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EIF5B VGNC VGNC:28420
Mus musculus EIF5B MGD MGI:2441772
Felis catus EIF5B VGNC VGNC:61799
Rattus norvegicus EIF5B RGD RGD:735017
Macaca mulatta EIF5B VGNC VGNC:72148
Canis familiaris EIF5B VGNC VGNC:40294
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