PUM1 - pumilio RNA binding family member 1 Gene

中文名称：pumilio RNA 结合家族成员 1

种属: Homo sapiens

同用名: PUMH; HSPUM; PUMH1; PUML1; SCA47

关于 PUM1

功能概要

该基因编码 PUF 家族的一个成员，进化上保守的 RNA 结合蛋白，与果蝇的 Pumilio 蛋白和秀丽隐杆线虫的 fem-3 mRNA 结合因子蛋白相关。编码的蛋白质包含一个序列特异性 RNA 结合结构域，该结构域由八个重复序列和 N 和 C 末端侧翼区域组成，并通过结合其 3' 非翻译区作为特定 mRNA 的翻译调节剂。编码蛋白在无脊椎动物和低等脊椎动物中的进化保守功能表明，人类蛋白可能参与胚胎发生、细胞发育和分化的翻译调节。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]