DOCK4 - dedicator of cytokinesis 4 Gene

中文名称：胞质分裂的奉献者 4

种属: Homo sapiens

关于 DOCK4

功能概要

该基因是胞质分裂 (DOCK) 家族的成员，编码具有 DHR-1 (CZH-1) 结构域、DHR-2 (CZH-2) 结构域和 SH3 结构域的蛋白质。这种膜相关的细胞质蛋白起鸟嘌呤核苷酸交换因子的作用，并参与细胞间粘附连接的调节。该基因的突变与卵巢癌、前列腺癌、神经胶质瘤和结直肠癌有关。已经描述了编码不同蛋白质同种型的选择性剪接变体，但只有一种已被完全表征。[RefSeq 提供，2008 年 7 月]

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]