1. Gene
  2. TOX - thymocyte selection associated high mobility group box Gene

TOX - thymocyte selection associated high mobility group box Gene

中文名称:胸腺细胞选择相关的高迁移率组框

种属: Homo sapiens

同用名: TOX1

基因 ID: 9760 | 基因类型: protein coding

关于 TOX

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:58,805,412-59,119,147 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 9.9), brain (RPKM 6.2) and 19 other tissues.

功能概要

该基因编码的蛋白质包含一个 HMG 盒 DNA 结合域。 HMG 盒存在于许多参与染色质组装、转录和复制的真核蛋白质中。这种蛋白质可能起到调节 T 细胞发育的作用。[RefSeq 提供,2009 年 4 月]

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

TOX 基因产物(1)

mRNA Protein Name
NM_014729.3 NP_055544.1 thymocyte selection-associated high mobility group box protein TOX
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in natural killer cell differentiation IMP
IMP: 通过突变表型推断
21126536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TOX 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (261 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 526 a.a.
蛋白主名 其他名称

thymocyte selection-associated high mobility group box protein TOX

thymus high mobility group box protein TOX

TOX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TOX O94900 KRTAP12-1 Homo sapiens P59990
Validated Y2H
32296183
Intra TOX O94900 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra TOX O94900 GRAP Homo sapiens Q13588
Validated Y2H
32296183
Intra TOX O94900 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra TOX O94900 DMRTB1 Homo sapiens Q96MA1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Astigmatism
Parapsoriasis

Digitate Dermatosis

Parapsoriasis En Plaque

Parapsoriasis En Plaques

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TOX VGNC VGNC:36228
Canis familiaris TOX VGNC VGNC:47717
Rattus norvegicus TOX RGD RGD:1310455
Felis catus TOX VGNC VGNC:66458
Mus musculus TOX MGD MGI:2181659
Macaca mulatta TOX VGNC VGNC:79165
Macaca fascicularis TOX NCBI NCBI:102136399
Susscrofa domestica TOX NCBI
Others TOX NCBI