1. Gene
  2. MRC2 - mannose receptor C type 2 Gene

MRC2 - mannose receptor C type 2 Gene

中文名称:甘露糖受体 C 型 2

种属: Homo sapiens

同用名: CD280; UPARAP; CLEC13E; ENDO180

基因 ID: 9902 | 基因类型: protein coding

关于 MRC2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,627,670-62,693,597 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues.

功能概要

该基因编码甘露糖受体蛋白家族的一个成员,该家族包含一个 II 型纤连蛋白结构域和多个 C 型凝集素样结构域。编码的蛋白质通过介导胶原配体的内化和溶酶体降解在细胞外基质重塑中发挥作用。该基因的表达可能在多种恶性肿瘤 (包括乳腺癌、神经胶质瘤和转移性骨病) 的肿瘤发生和转移中发挥作用。[RefSeq 提供,2012 年 2 月]

This gene encodes a member of the Mannose Receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast Cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

MRC2 基因产物(1)

mRNA Protein Name
NM_006039.5 NP_006030.2 C-type mannose receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
10636902 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7904248 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in collagen catabolic process IDA
IDA: 通过直接分析推断
12972549 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MRC2 蛋白结构

fn2

fn2: Fibronectin type II domain (187 - 228)

Lectin_C

Lectin_C: Lectin C-type domain (256 - 361)

Lectin_C

Lectin_C: Lectin C-type domain (399 - 506)

Lectin_C

Lectin_C: Lectin C-type domain (539 - 645)

Lectin_C

Lectin_C: Lectin C-type domain (694 - 809)

Lectin_C

Lectin_C: Lectin C-type domain (844 - 952)

Lectin_C

Lectin_C: Lectin C-type domain (995 - 1109)

Lectin_C

Lectin_C: Lectin C-type domain (1143 - 1243)

Lectin_C

Lectin_C: Lectin C-type domain (1288 - 1394)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1479 a.a.
蛋白主名 其他名称

C-type mannose receptor 2

C-type lectin domain family 13 member E

MRC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
MRC2 Q9UBG0 Col1a1 Rattus norvegicus P02454
SPR
26481812
种属间
MRC2 Q9UBG0 Col1a1 Rattus norvegicus P02454 26481812
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MRC2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700875 MRC2 Protein, Human (HEK293, His) Q9UBG0 (G31-P530) ≥95%

MRC2 抗体

目录号 产品名 应用 反应物种
HY-P82619 MRC2 Antibody (YA2364) WB Human

关联疾病

疾病名称 别名
Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System

Gliofibroma
Deafness, X-Linked 6

DFNX6

X-Linked Deafness 6

Deafness, X-Linked, 6

Deafness, X-Linked, Type 6

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii

OI3

Oi, Type Iii

Osteogenesis Imperfecta Type 3

Oi Type Iii

Oi Type 3

Progressive Deforming Osteogenesis Imperfecta

Severe Osteogenesis Imperfecta

Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

Progressively Deforming Oi

Osteogenesis Imperfecta 3

Oi-Iii

Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MRC2 VGNC VGNC:43360
Felis catus MRC2 VGNC VGNC:63579
Rattus norvegicus MRC2 RGD RGD:1559436
Mus musculus MRC2 MGD MGI:107818
Bos taurus MRC2 VGNC VGNC:31599
Macaca mulatta MRC2 VGNC VGNC:74784
Others MRC2 NCBI