2. 重组蛋白
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. Mannose Receptor
  7. MRC2 蛋白, Human (HEK293, His)

MRC2 蛋白, Human (HEK293, His)

目录号: HY-P700875
产品使用指南

MRC2 蛋白可能充当具有钙依赖性凝集素活性的内吞凝集素受体。它通过网格蛋白介导的内吞作用内化糖基化配体，并将其释放在内体中。MRC2可能控制纤溶酶原激活系统中的PLAUR/PLAU水平，调节细胞表面蛋白酶活性。它有助于细胞外胶原蛋白基质的细胞摄取、重塑和降解，影响癌症和组织破坏性疾病中的胶原蛋白周转。MRC2 与基质金属蛋白酶协作，与 I 型胶原蛋白相互作用，与 PLAUR/UPAR 和 PLAU/pro-UPA 形成三分子复合物，并直接与 V 型胶原蛋白结合，突出其在与细胞外基质动力学相关的细胞过程中的多功能作用。MRC2 蛋白, Human (HEK293, His) 是重组的 MRC2 蛋白，由 HEK293 表达，带有 C-His 标签。MRC2 蛋白, Human (HEK293, His) 全长 500 个氨基酸，分子量为 65-75 kDa。

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描述

MRC2 Protein potentially acts as an endocytotic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands through clathrin-mediated endocytosis, releasing them in endosomes. MRC2 may control PLAUR/PLAU levels in the plasminogen activation system, regulating cell surface protease activity. It contributes to cellular uptake, remodeling, and degradation of extracellular collagen matrices, influencing collagen turnover in cancer and tissue destructive diseases. MRC2 collaborates with matrix metalloproteinases, interacting with type I collagen, forming a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly engaging with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293, with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.
研究背景

MRC2 蛋白可能作为具有钙依赖性凝集素活性的内吞凝集素受体发挥作用。它通过从细胞外空间内化糖基化配体，通过网格蛋白介导的内吞作用将它们释放到内体隔室中来发挥作用。MRC2可能参与纤溶酶原激活系统，控制PLAUR/PLAU的细胞外水平，从而调节细胞表面的蛋白酶活性。此外，它还有助于细胞外胶原蛋白基质的细胞摄取、重塑和降解，可能影响癌症进展和其他慢性组织破坏性疾病期间的胶原蛋白周转。MRC2 与基质金属蛋白酶 (MMP) 协同参与细胞外基质的重塑。它与 I 型胶原/COL1A1 的 C 端区域相互作用，与 PLAUR/UPAR 和 PLAU/pro-UPA 形成三分子复合物，并直接与 V 型胶原相互作用，突出了其在与细胞外基质相关的细胞过程中的多功能作用动力学。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

Q9UBG0 (G31-P530)
基因 ID
蛋白结构
N-term
MRC2 (G31-P530)
Accession # Q9UBG0
His
C-term
同用名
C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)
分子量

65-75 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

MRC2 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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