2. Gene
  3. SEC16A - SEC16 homolog A, endoplasmic reticulum export factor Gene

SEC16A - SEC16 homolog A, endoplasmic reticulum export factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC16 同系物 A，内质网输出因子

种属: Homo sapiens

同用名: p250; SEC16L; KIAA0310

基因 ID: 9919 | 基因类型: protein coding

关于 SEC16A

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,440,105-136,484,740 (from NCBI)

This gene has 15 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 11.7), bone marrow (RPKM 11.4) and 25 other tissues.

功能概要

该基因编码的蛋白质构成了 Sec16 复合体的一部分。这种蛋白质在从内质网 (ER) 到高尔基体的蛋白质转运中起作用，并在过渡 ER 处介导 COPII 囊泡形成。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2013 年 2 月]

This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]

SEC16A 基因产物(2)

mRNA Protein Name
NM_001276418.2 NP_001263347.1 protein transport protein Sec16A isoform 2
NM_014866.2 NP_055681.1 protein transport protein Sec16A isoform 1

SEC16A 蛋白结构

Sec16

Sec16: Vesicle coat trafficking protein Sec16 mid-region (1448 - 1550)

Sec16_C

Sec16_C: Sec23-binding domain of Sec16 (1621 - 1854)

  • 0
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  • 2000
  • 2357 a.a.
蛋白主名 其他名称

protein transport protein Sec16A

protein SEC16 homolog A

SEC16A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEC16A O15027 DOCK7 Homo sapiens Q96N67
Anti Bait CoIP
29187380
Intra SEC16A O15027 NBEAL2 Homo sapiens Q6ZNJ1
Anti Tag CoIP
29187380
Intra SEC16A O15027 NBEAL2 Homo sapiens Q6ZNJ1
Anti Bait CoIP
29187380
Intra SEC16A O15027 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
25201882
Intra SEC16A O15027 LRRK2 Homo sapiens Q5S007
Confocal
25201882
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma
Amelogenesis Imperfecta, Type Iiia

Ai3

Adhcai

Amelogenesis Imperfecta Type 3

AI3A

Amelogenesis Imperfecta, Type Iii

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant

Amelogenesis Imperfecta Type 3a

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iii

Hypocalcified Amelogenesis Imperfecta

Amelogenesis Imperfecta, Type 3

Amelogenesis Imperfecta, Hypomineralization Type

Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3a

Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12609 SEC16A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SEC16A VGNC VGNC:64963
Macaca mulatta SEC16A VGNC VGNC:77326
Mus musculus SEC16A MGD MGI:2139207
Canis familiaris SEC16A VGNC VGNC:45965
Rattus norvegicus SEC16A RGD RGD:2322350
Bos taurus SEC16A VGNC VGNC:34406
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