2. Gene
  3. GFPT2 - glutamine-fructose-6-phosphate transaminase 2 Gene

GFPT2 - glutamine-fructose-6-phosphate transaminase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氨酰胺-果糖-6-磷酸转氨酶 2

种属: Homo sapiens

同用名: GFAT; GFAT2; GFAT 2

基因 ID: 9945 | 基因类型: protein coding

关于 GFPT2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,300,698-180,353,336 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 1 paralogue. Broad expression in appendix (RPKM 10.6), gall bladder (RPKM 9.6) and 23 other tissues.

功能概要

预测可启用谷氨酰胺-果糖-6-磷酸转氨酶 (异构化) 活性。预计参与 UDP-N-乙酰葡糖胺代谢过程；果糖 6-磷酸代谢过程；和蛋白质 N-连接的糖基化。预计在白血病抑制因子的细胞反应上游或细胞反应中起作用。预测位于胞质溶胶中。与 2 型糖尿病有关。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]

GFPT2 基因产物(1)

mRNA Protein Name
NM_005110.4 NP_005101.1 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IDA
IDA: 通过直接分析推断
35229715 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in UDP-N-acetylglucosamine biosynthetic process IDA
IDA: 通过直接分析推断
35229715 GOA
involved in fructose 6-phosphate metabolic process IDA
IDA: 通过直接分析推断
35229715 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GFPT2 蛋白结构

GATase_2

GATase_2: Glutamine amidotransferases class-II (2 - 59)

GATase_2

GATase_2: Glutamine amidotransferases class-II (79 - 210)

SIS

SIS: SIS domain (364 - 489)

SIS

SIS: SIS domain (535 - 664)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
蛋白主名 其他名称

glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

D-fructose-6-phosphate amidotransferase 2

GFPT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GFPT2 O94808 GFPT1 Homo sapiens Q06210
Anti Tag CoIP
33961781
种属内
GFPT2 O94808 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 19

AD19

Alzheimer'S Disease 19

Alzheimer Disease 19, Late-Onset

Alzheimer Disease 19 Late Onset

Late-Onset Alzheimer Disease

Alzheimer Disease, Late Onset, Susceptibility To, Type 19

Alzheimer Disease, Late Onset
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05385 GFPT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GFPT2 RGD RGD:1303097
Felis catus GFPT2 VGNC VGNC:62528
Bos taurus GFPT2 VGNC VGNC:29331
Canis familiaris GFPT2 VGNC VGNC:41188
Mus musculus GFPT2 MGD MGI:1338883
Macaca mulatta GFPT2 VGNC VGNC:72916
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