1. Gene
  2. USP3 - ubiquitin specific peptidase 3 Gene

USP3 - ubiquitin specific peptidase 3 Gene

中文名称:泛素特异性肽酶 3

种属: Homo sapiens

同用名: UBP; SIH003

基因 ID: 9960 | 基因类型: protein coding

关于 USP3

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,504,593-63,594,633 (from NCBI)

This gene has 21 transcripts (splice variants), 200 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 9.8), spleen (RPKM 5.3) and 25 other tissues.

功能概要

启用组蛋白结合活性和硫醇依赖性去泛素化酶。参与多个过程,包括 DNA 修复;组蛋白去泛素化;和调节蛋白质的稳定性。位于多个细胞成分中,包括 Flemming 体;细胞质核糖核蛋白颗粒;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables histone binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP3 基因产物(2)

mRNA Protein Name
NM_001256702.2 NP_001243631.1 ubiquitin carboxyl-terminal hydrolase 3 isoform 2
NM_006537.4 NP_006528.2 ubiquitin carboxyl-terminal hydrolase 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
17980597 GOA
enables histone H2A deubiquitinase activity IMP
IMP: 通过突变表型推断
17980597 GOA
enables histone H2B deubiquitinase activity IMP
IMP: 通过突变表型推断
17980597 GOA
enables histone binding IPI
IPI: 通过物理相互作用推断
17980597 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IMP
IMP: 通过突变表型推断
17980597 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: 通过直接分析推断
17980597 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
17980597 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USP3 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (29 - 106)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (159 - 508)

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  • 520 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 3

deubiquitinating enzyme 3

直系同源

种属 基因名 来源 基因 ID
Felis catus USP3 VGNC VGNC:66877
Macaca mulatta USP3 VGNC VGNC:78746
Mus musculus USP3 MGD MGI:2152450
Canis familiaris USP3 VGNC VGNC:48187
Bos taurus USP3 VGNC VGNC:36721
Rattus norvegicus USP3 RGD RGD:1308852
Others USP3 NCBI