TNFSF15 - TNF superfamily member 15 Gene

中文名称：TNF 超家族成员 15

种属: Homo sapiens

同用名: TL1; TL1A; VEGI; TNLG1B; VEGI192A

基因 ID: 9966 | 基因类型: protein coding

关于 TNFSF15

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,784,635-114,806,039 (from NCBI)

This gene has 2 transcripts (splice variants), 122 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues.

功能概要

该基因编码的蛋白质是一种属于肿瘤坏死因子 (TNF) 配体家族的细胞因子。这种蛋白质在内皮细胞中大量表达，但不在 B 细胞或 T 细胞中表达。该蛋白的表达可由 TNF 和 IL-1 α 诱导。这种细胞因子是受体 TNFRSF25 和诱饵受体 TNFRSF21/DR6 的配体。它可以激活 NF-kappaB 和 MAP 激酶，并作为自分泌因子诱导内皮细胞凋亡。还发现这种细胞因子可抑制内皮细胞增殖，因此可作为血管生成抑制剂发挥作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce Apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TNFSF15 基因产物(2)

mRNA	Protein	Name
NM_001204344.1	NP_001191273.1	tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
NM_005118.4	NP_005109.2	tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21300286	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within activation of NF-kappaB-inducing kinase activity	IDA IDA: 通过直接分析推断	11911831	GOA
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	11911831	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	11911831	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFSF15 蛋白结构

TNF

0
100
200
251 a.a.

蛋白主名

其他名称

tumor necrosis factor ligand superfamily member 15

TNF ligand-related molecule 1

重组 TNFSF15 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71913	TL1A/TNFSF15 Protein, Human	O95150 (L72-L251)	≥95%
HY-P71981	TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His)	O95150-2 (M1-L192)	≥95%
HY-P78447	TL1A/TNFSF15 Trimer Protein, Human (HEK293, His-Flag)	O95150-1 (D91-L251)	≥95%
HY-P700153AF	Animal-Free TL1A/TNFSF15 Protein, Human (His)	O95150 (Q58-L251)	≥95%
HY-P701048	TL1A/TNFSF15 Protein, Human (180a.a, HEK293, His)	O95150-1 (L72-L251)	≥95%

关联疾病

疾病名称

别名

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diverticulitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease 15

IBD15

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Inflammatory Bowel Disease 5

IBD5

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Inflammatory Bowel Disease 19

Inflammatory Bowel Disease 19	IBD19
Bowel Disease, Inflammatory, Type 19

Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Ileitis

Crohn'S Ileitis

Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2	Temporal Epilepsy, Familial
ETL2	Ftle
Epilepsy, Familial Temporal Lobe	Familial Temporal Lobe Epilepsy

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P990007	Tulisokibart	Inhibitor	99.00%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14826	TNFSF15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990006	Duvakitug	Inhibitor	99.76%	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TNFSF15	VGNC	VGNC:36174
Canis familiaris	TNFSF15	VGNC	VGNC:47671
Rattus norvegicus	TNFSF15	RGD	RGD:628735
Mus musculus	TNFSF15	MGD	MGI:2180140
Macaca mulatta	TNFSF15	VGNC	VGNC:78596
Felis catus	TNFSF15	VGNC	VGNC:66415
Macaca fascicularis	TNFSF15	NCBI	NCBI:102144578
Others	TNFSF15	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TNFSF15 - TNF superfamily member 15 Gene

关于 TNFSF15

功能概要

TNFSF15 基因产物(2)

TNFSF15 蛋白结构

重组 TNFSF15 蛋白

关联疾病

直系同源

热门区域

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TNFSF15 - TNF superfamily member 15 Gene

关于 TNFSF15

功能概要

TNFSF15 基因产物(2)

TNFSF15 蛋白结构

重组 TNFSF15 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z