TL1A/TNFSF15 蛋白, Human

TL1A/TNFSF15 Protein, the receptor for TNFRSF25 and TNFRSF6B, activates NF-kappa-B and promotes caspase activation, leading to apoptosis. It also inhibits vascular endothelial growth and angiogenesis in vitro. Operating as a homotrimer, it plays a crucial role in diverse cellular processes, including immune response and apoptosis regulation. TL1A/TNFSF15 Protein, Human is the recombinant human-derived TL1A/TNFSF15 protein, expressed by E. coli , with tag free. The total length of TL1A/TNFSF15 Protein, Human is 180 a.a., with molecular weight of ~20.5 kDa.

TL1A/TNFSF15 蛋白作为 TNFRSF25 和 TNFRSF6B 的受体，促进 NF-κ-B 的激活，并促进 Caspases 的激活，导致细胞凋亡。此外，它在体外对血管内皮生长和血管生成具有抑制作用。该蛋白质作为同源三聚体发挥作用，强调了其在多种细胞过程中的作用，包括免疫反应和细胞凋亡调节。

Measured by its ability to induce apoptosis of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 3.752 ng/ml, corresponding to a specific activity is 2.665×10^5 units/mg.

Human

E. coli

Tag Free

O95150 (L72-L251)

9966  [NCBI]

LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL

Approximately 20.5 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm solution of 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.