CCS - copper chaperone for superoxide dismutase Gene

中文名称：超氧化物歧化酶铜伴侣

种属: Homo sapiens

基因 ID: 9973 | 基因类型: protein coding

关于 CCS

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,593,185-66,606,019 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 18.8), spleen (RPKM 17.6) and 25 other tissues.

功能概要

超氧化物歧化酶的铜伴侣特异性地将 Cu 递送至铜/锌超氧化物歧化酶，并可能通过直接插入 Cu 辅助因子激活铜/锌超氧化物歧化酶。[RefSeq 提供，2008 年 7 月]

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]

CCS 基因产物(1)

mRNA	Protein	Name
NM_005125.2	NP_005116.1	copper chaperone for superoxide dismutase

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables copper ion binding	IDA IDA: 通过直接分析推断	9726962	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9726962	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9726962	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9726962	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCS 蛋白结构

HMA

Sod_Cu

0
100
200
274 a.a.

蛋白主名

其他名称

copper chaperone for superoxide dismutase

superoxide dismutase copper chaperone

CCS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCS	O14618	XIAP	Homo sapiens	P98170	Anti Tag CoIP	22508683
种属内	CCS	O14618	SOD1	Homo sapiens	P00441	Anti Tag CoIP	22508683
种属内	CCS	O14618	SOD1	Homo sapiens	P00441	Pull Down	12968035

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-111784	Inobrodib	Inhibitor	99.94%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107636	DC_AC50	Inducer	99.97%	否
HY-160005	LMP517	Inhibitor	99.58%	否
HY-147373	DA-PROTAC		/	否
HY-168202	CCS1477a	Control	/	否
HY-RS02176	CCS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCS	VGNC	VGNC:38919
Bos taurus	CCS	VGNC	VGNC:26991
Mus musculus	CCS	MGD	MGI:1333783
Rattus norvegicus	CCS	RGD	RGD:620403
Felis catus	CCS	VGNC	VGNC:81914
Macaca mulatta	CCS	VGNC	VGNC:70744
Others	CCS	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCS - copper chaperone for superoxide dismutase Gene

关于 CCS

功能概要

CCS 基因产物(1)

CCS 蛋白结构

CCS 蛋白互作信息

关联疾病

直系同源

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CCS - copper chaperone for superoxide dismutase Gene

关于 CCS

功能概要

CCS 基因产物(1)

CCS 蛋白结构

CCS 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z