2. Apoptosis
  3. Apoptosis
  4. Germanicol

Germanicol 是一种选择性抗肿瘤试剂，能够抑制人结肠癌细胞株 HCT-116 和 HT29 生长。Germanicol 通过染色质凝聚和DNA损伤，来诱导凋亡 (apoptosis)。

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Germanicol Chemical Structure

Germanicol Chemical Structure

CAS No. : 465-02-1

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Germanicol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage[1].

体外研究
(In Vitro)

Germanicol (0-100 µM；6 h 和 24 h) 对 HCT-116 和 HT29 人结肠癌细胞具有选择性、强效和剂量依赖性的细胞毒性。Germanicol 以剂量依赖性方式诱导 HCT-116 和 HT29 细胞死亡[1]。
Germanicol (0-100 µM；48 h) 以剂量依赖性方式诱导 HCT-116 结肠癌细胞凋亡[1]。
Germanicol (0-100 µM；0-48 h) 抑制 HCT-116 结肠癌细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Germanicol 相关抗体:

Cell Viability Assay[1]

Cell Line: Human colon cancer cell lines HCT-116 (colon), HT29 (colon) and Human colon fibroblast (CCD-18Co).
Concentration: 0, 5, 10, 20, 40 and 100 µM.
Incubation Time: 6 h and 24 h.
Result: Showed insignificant cytotoxicity below 20 μM and exhibited potent and dose-dependent cytotoxic effect on both HCT-116 and HT29 colon cancer cells at higher doses over 40 µM.

Apoptosis Analysis[1]

Cell Line: HCT-116 colon cancer cells.
Concentration: 0, 10, 40 and 100 µM.
Incubation Time: 48 h.
Result: Induced potent and dose-dependent chromatin condensation, accompanied by subsequent DNA damage.

Cell Migration Assay [1]

Cell Line: HCT-116 colon cancer cells.
Concentration: 0, 10, 40 and 100 µM.
Incubation Time: 0, 12, 24 and 48 h.
Result: Decreased cell migration tendency.
分子量

426.72

Formula

C30H50O
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

COA (267 KB)

产品使用指南 (1538 KB)
参考文献

Germanicol 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Germanicol465-02-1ApoptosisHCT-116HT29CCD-18CoMigrationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-121199
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