1. GPCR/G Protein
  2. GCGR
  3. Glucagon (22-29)

Glucagon (22-29) 是 Glucagon (19–29) 的部分激动剂。Glucagon 特异性抑制肝质膜 Ca2+ 泵,独立于腺苷酸环化酶激活。

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Custom Peptide Synthesis

Glucagon (22-29) Chemical Structure

Glucagon (22-29) Chemical Structure

CAS No. : 32204-93-6

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规格 价格 是否有货 数量
1 mg ¥560
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5 mg ¥1400
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10 mg ¥2080
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation[1][2].

体外研究
(In Vitro)

Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase, with a low potency (Ki=1 μM), similar to that of native glucagon[1].
Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon[2].
Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20-Asp21 residues[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1038.22

Formula

C49H71N11O12S

CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

FVQWLMNT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (96.32 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9632 mL 4.8159 mL 9.6319 mL
5 mM 0.1926 mL 0.9632 mL 1.9264 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9632 mL 4.8159 mL 9.6319 mL 24.0797 mL
5 mM 0.1926 mL 0.9632 mL 1.9264 mL 4.8159 mL
10 mM 0.0963 mL 0.4816 mL 0.9632 mL 2.4080 mL
15 mM 0.0642 mL 0.3211 mL 0.6421 mL 1.6053 mL
20 mM 0.0482 mL 0.2408 mL 0.4816 mL 1.2040 mL
25 mM 0.0385 mL 0.1926 mL 0.3853 mL 0.9632 mL
30 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.8027 mL
40 mM 0.0241 mL 0.1204 mL 0.2408 mL 0.6020 mL
50 mM 0.0193 mL 0.0963 mL 0.1926 mL 0.4816 mL
60 mM 0.0161 mL 0.0803 mL 0.1605 mL 0.4013 mL
80 mM 0.0120 mL 0.0602 mL 0.1204 mL 0.3010 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Glucagon (22-29)
目录号:
HY-P3617
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