2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. GPBAR-A

GPBAR-A 是一种特异性的胆汁酸受体 GPBAR1 的激动剂。GPBAR-A 可用于糖尿病的研究。

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GPBAR-A Chemical Structure

GPBAR-A Chemical Structure

CAS No. : 877052-79-4

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规格 价格 是否有货 数量
5 mg ￥5040
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

GPBAR-A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPBAR-A is a specific agonist of the bile acid receptor GPBAR1. GPBAR-A can be used for the research of diabetes mellitus[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.019 μM
Compound: 2
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
[PMID: 24007860]
HEK293 EC50
0.13 μM
Compound: 2
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
[PMID: 24007860]
HEK293 EC50
0.23 nM
Compound: 3
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
[PMID: 23148522]
体外研究
(In Vitro)

GPBAR-A (3 μM; 24-36 h) 在 GLUTag 细胞中，GPBAR-A 可刺激胰高血糖素样肽 (GLP-1) 的释放[1]。
GPBAR-A (3 μM; 24-36 h) 在原代结肠培养物中，可增加 4.2 倍的 GLP-1 释放[1]。
GPBAR-A (3 μM; 24-36 h) 在上部小肠培养物中，可增加 2.6 倍的 GLP-1 释放[1]。
GPBAR-A (3 μM; 24-36 h) 也可使 GLUTag 细胞中的 cAMP 浓度增加 57%[1]。
GPBAR-A (3 μM; 24-36 h) diazoxide (KATP 通道开放剂，340 μM) 和70 mM KCl 存在下增加 GLP-1 的分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPBAR-A 相关抗体:
分子量

484.37

Formula

C23H15F7N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPBAR-A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPBAR-A877052-79-4G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1GLP-1GLUTag cellscAMPprimary colonic culturesdiabetes mellitusInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
GPBAR-A
目录号：
HY-107612
需求量：

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