GRK6-IN-1

目录号: HY-142812 纯度: 99.64%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

GRK6-IN-1 (compound 18) 是 G 蛋白偶联受体激酶 6 (GRK6) 的有效抑制剂，IC₅₀ 为 120 nM。GRK6 是多发性骨髓瘤 (MM) 细胞存活所需的关键激酶。GRK6-IN-1 具有研究多发性骨髓瘤的潜力。

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GRK6-IN-1 Chemical Structure

CAS No. : 2677786-61-5

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3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1650	In-stock
1 mg	￥681	In-stock
5 mg	￥1500	In-stock
10 mg	￥2500	In-stock
25 mg	￥5500	In-stock
50 mg	现货	询价
100 mg		询价
200 mg		询价

or 大包装询价

* Please select Quantity before adding items.

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MCE 顾客使用本产品发表的 2 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC₅₀ of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
KMS-11	IC₅₀	0.34 μM Compound: 18	Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	0.44 μM Compound: 18	Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1 μM Compound: 18	Antiproliferative activity against human KMS11 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1 μM Compound: 18	Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1.1 μM Compound: 18	Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
LP-1	IC₅₀	1.9 μM Compound: 18	Antiproliferative activity against human LP1 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human LP1 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
RPMI-8226	IC₅₀	0.44 μM Compound: 18	Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
RPMI-8226	IC₅₀	2.1 μM Compound: 18	Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]

分子量

438.91

Formula

C₂₂H₂₃ClN₆O₂

CAS 号

2677786-61-5

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (113.92 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2784 mL	11.3919 mL	22.7837 mL
5 mM	0.4557 mL	2.2784 mL	4.5567 mL
10 mM	0.2278 mL	1.1392 mL	2.2784 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.64%

选择批次：

Data Sheet (604 KB) SDS (251 KB)

COA (269 KB) HNMR (287 KB) LCMS (96 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. [Content Brief]

GRK6-IN-1 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2784 mL	11.3919 mL	22.7837 mL	56.9593 mL
	5 mM	0.4557 mL	2.2784 mL	4.5567 mL	11.3919 mL
	10 mM	0.2278 mL	1.1392 mL	2.2784 mL	5.6959 mL
	15 mM	0.1519 mL	0.7595 mL	1.5189 mL	3.7973 mL
	20 mM	0.1139 mL	0.5696 mL	1.1392 mL	2.8480 mL
	25 mM	0.0911 mL	0.4557 mL	0.9113 mL	2.2784 mL
	30 mM	0.0759 mL	0.3797 mL	0.7595 mL	1.8986 mL
	40 mM	0.0570 mL	0.2848 mL	0.5696 mL	1.4240 mL
	50 mM	0.0456 mL	0.2278 mL	0.4557 mL	1.1392 mL
	60 mM	0.0380 mL	0.1899 mL	0.3797 mL	0.9493 mL
	80 mM	0.0285 mL	0.1424 mL	0.2848 mL	0.7120 mL
	100 mM	0.0228 mL	0.1139 mL	0.2278 mL	0.5696 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRK6-IN-12677786-61-5G Protein-coupled Receptor Kinase (GRK)GRK6multiple myelomasurvivalInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GRK6-IN-1

Customer Review

MCE 顾客使用本产品发表的 2 篇科研文献