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  3. GSK223

GSK223 是一种喹唑啉酮类 NOD1 通路的抑制剂,具有潜在抗炎活性。GSK223 能够选择性地抑制 iE-DAP 刺激下的 IL-8 释放,而不影响 TNF 受体、TLR2 或 NOD2 激动剂引起的 IL-8 分泌。GSK223 不对 RIP2 激酶活性产生直接抑制作用,。

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GSK223 Chemical Structure

GSK223 Chemical Structure

CAS No. : 899758-61-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity.

分子量

443.51

Formula

C21H18FN3O3S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

GSK223 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GSK223
目录号:
HY-118316
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