2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. GSK2332255B

GSK2332255B 是一种有效的、选择性的 TRPC3 和 TRPC6 拮抗剂，对大鼠 TRPC3 和大鼠 TRPC6 的 IC50 为 5 nM 和 4 nM。GSK2332255B 对 TRPC3/6 的选择性高于其他钙渗透通道。

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GSK2332255B Chemical Structure

GSK2332255B Chemical Structure

CAS No. : 1366233-41-1

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GSK2332255B 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].

IC50 & Target[1]

rTRPC3

5 nM (IC50)

rTRPC6

4 nM (IC50)

体外研究
(In Vitro)

Nuclear factor of activated T cells (NFAT) activation by Ang II ( angiotensin II) is blocked in a dose dependent manner by GSK255B (0.01, 0.1, and 1 μM) in HEK293T cells overexpressing TRPC3. GSK255B blocks NFAT activation by Ang II in HEK293T cells expressing a mutant TRPC6 channel with T70 and S322 mutated to glutamic acid (SETE)[1].
GSK255B (10 μM) blocks calcium entry stimulated by Phenylephrine (20 μM) in rat neonatal cardiac myocytes. GSK255B dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK2332255B 相关抗体:
分子量

411.88

Formula

C18H19ClFN3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK2332255B 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK2332255B1366233-41-1TRP ChannelTransient receptor potential channelsTRPC3TRPC6cellhypertrophyInhibitorinhibitorinhibit

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