2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. GPR55 GlyT
  4. GSK494581A

GSK494581A 是人类 GPR55 的特异性配体 (pEC50 为 6.8)，也是一种甘氨酸转运蛋白亚型 1 (GlyT1) 抑制剂。GSK494581A 可能通过与GPR55 结合来调控疼痛信号传导、骨形态发生以及血管内皮细胞形成。

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GSK494581A Chemical Structure

GSK494581A Chemical Structure

CAS No. : 909416-67-7

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GSK494581A 相关抗体

Top Publications Citing Use of Products

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GlyT1 GlyT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK494581A is a specific ligand for human GPR55 (pEC50 of 6.8) and also acts as an inhibitor of glycine transporter subtype 1 (GlyT1). GSK494581A may regulate pain signaling, bone morphogenesis, and vascular endothelial cell formation by binding to GPR55[1].

IC50 & Target

rGlyT1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
20 nM
Compound: GSK494581A
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
[PMID: 26575458]
分子量

514.58

Formula

C27H28F2N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK494581A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK494581A909416-67-7GPR55GlyTG protein-coupled receptor 55Glycine transportersInhibitorinhibitorinhibit

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