1. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  2. PPAR Calcium Channel Apoptosis
  3. GW7845

GW7845 是一种具有口服活性的,非噻唑烷二酮类酪氨酸衍生的 PPARγ 激动剂。GW7845 可有效抑制电压依赖性钙通道 (VDCC) 并放松加压动脉,使用 Ba2+ 作为电荷载体,IC50 为 3 μM。GW7845 诱导的细胞凋亡依赖于线粒体和凋亡体。GW7845 在原代 pro-B 细胞和 BU-11 细胞中诱导线粒体膜快速去极化和细胞色素 c 释放。

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GW7845 Chemical Structure

GW7845 Chemical Structure

CAS No. : 196809-22-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].

IC50 & Target[1]

PPARγ

 

L-type calcium channel

 

分子量

500.54

Formula

C29H28N2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GW7845
目录号:
HY-121746
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