2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. PPAR Calcium Channel Apoptosis
  4. GW7845

GW7845 是一种具有口服活性的，非噻唑烷二酮类酪氨酸衍生的 PPARγ 激动剂。GW7845 可有效抑制电压依赖性钙通道 (VDCC) 并放松加压动脉，使用 Ba2+ 作为电荷载体，IC50 为 3 μM。GW7845 诱导的细胞凋亡依赖于线粒体和凋亡体。GW7845 在原代 pro-B 细胞和 BU-11 细胞中诱导线粒体膜快速去极化和细胞色素 c 释放。

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GW7845 Chemical Structure

GW7845 Chemical Structure

CAS No. : 196809-22-0

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GW7845 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].

IC50 & Target[1]

PPARγ

 

L-type calcium channel

 

分子量

500.54

Formula

C29H28N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GW7845 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW7845196809-22-0GW 7845GW-7845PPARCalcium ChannelApoptosisPeroxisome proliferator-activated receptorsCa2+ channelsCa channelsVDCCBa2+mitochondriaapoptosomecytochrome cpro-BBU-11Inhibitorinhibitorinhibit

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