2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. iGluR Cytochrome P450
  4. GYKI-47261 dihydrochloride

GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂，IC50为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。

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GYKI-47261 dihydrochloride Chemical Structure

GYKI-47261 dihydrochloride Chemical Structure

CAS No. : 1217049-32-5

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GYKI-47261 dihydrochloride 相关抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[1][2].

体内研究
(In Vivo)

GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57 black mice, weighing 23-30 g[1]
Dosage: 20 mg/kg
Administration: I.p.
Result: Reversed the MPTP-induced decrease in striatal concentrations.
分子量

395.71

Formula

C18H17Cl3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GYKI-47261 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

GYKI-472611217049-32-5GYKI47261GYKI 47261iGluRCytochrome P450Ionotropic glutamate receptorsCYPsneurotoxicityParkinsonsdiseaseantiischemiceanticonvulsivecompetitiveInhibitorinhibitorinhibit

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产品名称：
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