2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-42

HDAC6-IN-42 (compound 2b) 作为一种 HDAC6 抑制剂 (IC50=0.009 μM)，展现出了显著的抗白血病活性和与 Decitabine (HY-A0004) 的协同效应，这表明它可用于 Acute Myeloid Leukemia (AML) 的研究。

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HDAC6-IN-42 Chemical Structure

HDAC6-IN-42 Chemical Structure

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HDAC6-IN-42 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor (IC50=0.009 μM). HDAC6-IN-42 shows significant anti-leukemia activity and synergistic effect with Decitabine (HY-A0004). HDAC6-IN-42 can be used for the AML research[1].

IC50 & Target

HDAC6

0.009 μM (IC50)

体外研究
(In Vitro)

HDAC6-IN-42 对 3 种白血病细胞株 (HAL01：2.32±0.77 μM，HL60：2.04±0.62 μM，Jurkat：3.08±0.59 μM)的抗增殖活性比HPOB 提高 5 倍以上[1]。
HDAC6-IN-42 对 HDAC6 具有更高的选择性 (IC50=0.787 μM；SIHDAC2/6=87) 和 HDAC3 (IC50=0.520 μM；SIHDAC3/6=58) 与 HDAC1 相比 (IC50=0.228 μM；Sihdac1/6=25)[1]。
HDAC6-IN-42 (1.5 μM；48 h) 对健康成纤维细胞表现出没有细胞毒性，并表现出晚期凋亡细胞百分比的显著增加[1]。
HDAC6-IN-42 在诱导与 Decitabine (HY-A0004) 特异性药物协同作用对抗 AML 细胞方面表现出色[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-42 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HAL01 (B-cell acute lymphoblastic leukemia or B-ALL), HL60 (acute myeloid leukemia or AML), and Jurkat (T-cell acute lymphoblastic leukemia or T-ALL)
Concentration:
Incubation Time:
Result: Exhibited antiproliferative activities in the single digit micromolar range against all three cell lines and thus exceeded the activity of HPOB.

Western Blot Analysis[1]

Cell Line: leukemic cell lines (K562, DND41, Jurkat, SUPB15, REH, Kasumi 2, 697, PEER, HAL01, MV4-11, MOLM13 and HL60) and healthy fibroblasts (F107 and F188)
Concentration: 0.2, 0.4, 0.8, 1.3 μM
Incubation Time: 24 h
Result: Increased α-tubulin acetylation while affecting H3 acetylation to a lesser extent.
分子量

441.50

Formula

C24H28FN3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-42 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-42HDACHistone deacetylasesHADCLeukemia cell linesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161516
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