2. Stem Cell/Wnt
  3. Hedgehog
  4. Hedgehog IN-5

Hedgehog IN-5是一种具有口服活性的小分子 hedgehog 通路抑制剂。Hedgehog IN-5 可用于纤维化疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Hedgehog IN-5 Chemical Structure

Hedgehog IN-5 Chemical Structure

CAS No. : 1544681-93-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Hedgehog IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. Hedgehog IN-5 can be used for the research of fibrotic disease[1].

体内研究
(In Vivo)

建模方法：Bleomycin (HY-108345) (3 mg/kg; 气管内注射; 持续 8 天) 诱导大鼠肺纤维化模型。 Hedgehog IN-5 (5-30 mg/kg; 造模 8 天后口服; 每天一次，连续 2 周) 对 Bleomycin (HY-108345) 诱导的大鼠肺纤维化模型中在多个病理评价指标上有明显的抑制肺纤维化进程的治疗作用[1]。
建模方法： CCL4 (以 0.5 μL/g 的剂量溶于橄榄油中; 口服; 每周 3 次，共 4 周) 诱导 C57BL/6 小鼠肝纤维化模型。 Hedgehog IN-5 (5-20 mg/kg; 造模当天口服; 每天一次，连续 4 周) 在 CCL4 诱导 C57BL/6 小鼠肝纤维化模型中显示出一定的抑制 CCl4 诱导的肝纤维化的趋势, 主要表现为减轻肝细胞变性和坏死的程度以及减少纤维化的面积[1]。
Hedgehog IN-5 (10-20 mg/kg, 20mg/kg (联合 BIBF1120 (50 mg/kg); 口服; 每天一次, 持续 20 天) 单独或联合 BIBF1120 均可显著抑制博莱霉素诱导的肺组织炎症和纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Unilateral pulmonary fibrosis in SD rat model[1]
Dosage: 5 mg/kg, 15 mg/kg, 30 mg/kg
Administration: Oral administration after 8 days of moulding; once daily for 2 weeks
Result: Reduced the scores of Bleomycin (HY-108345)-treated mice, significantly.
Collagen content in the lungs as well as myofibroblasts were quantified to assess the antifibrotic effect of Hedgehog IN-5, α-SMA protein percentage was significantly reduced with 30 mg/kg dose and collagen content was not significantly changed.
Animal Model: CCL4-induced liver fibrosis model in C57BL/6 mice[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Oral administration on the day of moulding; Once a day for four weeks
Result: Showed slow weight gain after one week and no significant weight gain after two weeks at the dose of 20 mg/kg.
Serum biochemical detection in peripheral blood showed that ALT and AST were significantly reduced but TBIL had no change at the dose of 20mg/kg.
Liver histopathological analysis showed that the liver injury score decreased and the fibrosis area of liver tissue decreased.
分子量

534.02

Formula

C27H31ClF3N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hedgehog IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hedgehog IN-51544681-93-7Hedgehog IN5Hedgehog IN 5Hedgehogfibrotic diseasesinflammationliver fibrosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Hedgehog IN-5
目录号：
HY-153730
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z