2. Anti-infection
  3. Antibiotic
  4. Bleomycin

Bleomycin  (Synonyms: 博来霉素)

目录号: HY-108345
产品使用指南

摩尔计算器

Bleomycin 是一种糖肽抗生素。Bleomycin 对一系列的淋巴瘤、头颈部癌症和生殖细胞肿瘤具有强大的抗肿瘤活性。Bleomycin 可用于癌症和化疗的研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Bleomycin sulfate。

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Bleomycin Chemical Structure

Bleomycin Chemical Structure

CAS No. : 11056-06-7

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Bleomycin 的其他形式现货产品:

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Other Forms of Bleomycin:

Bleomycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy[1][2][3][4].

IC50 & Target

Glycopeptide

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
53 μM
Compound: Bleomycin
Concentration required to reduce to 50% the number of MCF-7 cells with respect to untreated control after exposure to compound for 24 h
Concentration required to reduce to 50% the number of MCF-7 cells with respect to untreated control after exposure to compound for 24 h
[PMID: 12477361]
体外研究
(In Vitro)

Bleomycin (0-4 mU/mL; 1 h) induces double-strand break in V79 cells[2].
Bleomycin (0-1 mU/mL; 1 h) reduces migration of DNA from S-phase cells[2].
Bleomycin (0-3 μg/mL; 1 h) induces chromatid aberrations in G2 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bleomycin 相关抗体:
体内研究
(In Vivo)

Bleomycin (1 mg and 10 μg; retro-orbitary sinus injection once) affects cells in mitosis, induces apoptosis in tumor models[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice with LPB and B16F0 tumours[4]
Dosage: 1 mg and 10 μg
Administration: Retro-orbitary sinus injection; 1 mg and 10 μg once
Result: Decreased in the fraction of cells in mitosis in both tumours, induced cell apoptosis after the electric pulses delivery, inceased the amount of atypical cells in LPB tumours.
Clinical Trial
CAS 号
中文名称

博来霉素；博莱霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bleomycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bleomycin11056-06-7博来霉素博莱霉素AntibioticantibioticV79antitumourcancermigrationdouble-strand breaktumourInhibitorinhibitorinhibit

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