2. Academic Validation
  3. The hematopoietic activity of EPO is unfavorable to the treatment of bleomycin-induced pulmonary fibrosis in mice

The hematopoietic activity of EPO is unfavorable to the treatment of bleomycin-induced pulmonary fibrosis in mice

  • Biochem Biophys Res Commun. 2024 Dec 20:739:150951. doi: 10.1016/j.bbrc.2024.150951.
Pengfei Wu 1,  Wen Zhang 2,  Xitong Zuo 3,  Shengran Liu 3,  Tianrong Jin 4,  Jialin Jia 3,  Bangwei Luo 5,  Guansong Wang 6,  Zhiren Zhang 7
Affiliations

Affiliations

  • 1 Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Department of Respiratory and Critical Care Medicine, Sichuan Science City Hospital, Mianyang, Sichuan, China.
  • 2 Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
  • 3 Institute of Immunology, Third Military Medical University, Chongqing, China.
  • 4 Medical College of Chongqing University, Chongqing, China.
  • 5 Institute of Immunology, Third Military Medical University, Chongqing, China. Electronic address: luo6341@tmmu.edu.cn.
  • 6 Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address: wanggs@tmmu.edu.cn.
  • 7 Institute of Immunology, Third Military Medical University, Chongqing, China. Electronic address: zhangzhiren@tmmu.edu.cn.
PMID: 39547119 DOI: 10.1016/j.bbrc.2024.150951
Abstract

The main function of erythropoietin (EPO) is to promote hematopoiesis and improve anemia. In addition, EPO also has many non-hematopoietic effects such as anti-inflammation, anti-apoptosis and anti-oxidation. To achieve the protective effects, large doses of EPO are required, so the probability of side effects increases. Previous studies have revealed that EPO can improve pulmonary fibrosis in mice, but it has not been clarified whether the hematopoiesis of EPO contributes to amelioration of pulmonary fibrosis and whether EPO improves overall mortality. Our results show that EPO decreases hydroxyproline content, α-sma and col-1 protein levels in mice with bleomycin-induced pulmonary fibrosis. However, compared with the control group, the weight loss and mortality rate of the EPO group were not improved, while the number of red blood cells (RBCs), hemoglobin (Hb), red cell width distribution-coefficient of variation (RDW-CV) and hematocrit (HCT) were significantly higher. Furthermore, we observed massive thrombosis in the lung of EPO treated lung fibrosis mice but not in control mice. Therefore, our results show that in the condition of lung fibrosis, the hematopoietic activity of exogenous EPO is not conducive to its tissue protective effect.

Keywords

Erythropoietin; Fibrosis; Thrombosis.

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