2. Anti-infection
  3. Dengue virus Flavivirus SARS-CoV
  4. HeE1-2Tyr

HeE1-2Tyr 是一种 pyridobenzothiazole，是一种黄病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。HeE1-2Tyr 在体外显着抑制西尼罗河、登革热和 SARS-CoV-2 RdRps (IC50 为 27.6 µM) 的活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HeE1-2Tyr Chemical Structure

HeE1-2Tyr Chemical Structure

CAS No. : 2245195-67-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2500
In-stock
1 mg ￥830
In-stock
5 mg ￥1950
In-stock
10 mg ￥3200
In-stock
25 mg ￥5400
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

HeE1-2Tyr 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro[1][2].

IC50 & Target

Flavivirus RNA dependent RNA polymerases (RdRp)[1]
SARS-CoV-2 RdRps>[2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 CC50
> 100 μM
Compound: 1; PBTZ
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay
[PMID: 32435384]
Huh-7 EC50
0.4 μM
Compound: 1; PBTZ
Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay
Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay
[PMID: 32435384]
Huh-7 EC50
1.7 μM
Compound: 1; PBTZ
Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
[PMID: 32435384]
Huh-7 EC50
2.1 μM
Compound: 1; PBTZ
Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
[PMID: 32435384]
Huh-7 EC50
2.8 μM
Compound: 1; PBTZ
Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
[PMID: 32435384]
Huh-7 EC50
2.8 μM
Compound: 1; PBTZ
Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
[PMID: 32435384]
体外研究
(In Vitro)

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM[1].
Additionally, upon infection of human HEK 293 cells (CC50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 µM[1].
HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HeE1-2Tyr 相关抗体:
分子量

582.67

Formula

C33H30N2O6S
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (171.62 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7162 mL 8.5812 mL 17.1624 mL
5 mM 0.3432 mL 1.7162 mL 3.4325 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

HeE1-2Tyr 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7162 mL 8.5812 mL 17.1624 mL 42.9059 mL
5 mM 0.3432 mL 1.7162 mL 3.4325 mL 8.5812 mL
10 mM 0.1716 mL 0.8581 mL 1.7162 mL 4.2906 mL
15 mM 0.1144 mL 0.5721 mL 1.1442 mL 2.8604 mL
20 mM 0.0858 mL 0.4291 mL 0.8581 mL 2.1453 mL
25 mM 0.0686 mL 0.3432 mL 0.6865 mL 1.7162 mL
30 mM 0.0572 mL 0.2860 mL 0.5721 mL 1.4302 mL
40 mM 0.0429 mL 0.2145 mL 0.4291 mL 1.0726 mL
50 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.8581 mL
60 mM 0.0286 mL 0.1430 mL 0.2860 mL 0.7151 mL
80 mM 0.0215 mL 0.1073 mL 0.2145 mL 0.5363 mL
100 mM 0.0172 mL 0.0858 mL 0.1716 mL 0.4291 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HeE1-2Tyr2245195-67-7Dengue virusFlavivirusSARS-CoVDENVSARS coronavirusRdRpflavivirusSARS-CoV-2WestNileDengueInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HeE1-2Tyr
目录号：
HY-100749
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z