Helenalin 

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding^[1][2].

Helenalin (10 μM；20-120 分钟) 在 80 分钟后完全抑制 NF-κB DNA 结合^[1]。
Helenalin 是一种抗炎、抗癌的植物化学物质，是一种周期性 Skp2 积累的有效抑制剂，一种 F-box 蛋白，在 S 期进展期间介导 SCF E3 连接酶泛素化和两种 CKI 的降解^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Helenalin (25 mg/kg；腹腔注射；6 至 12 小时) 对未成熟的雄性 ICR 小鼠给药，导致肝脏谷胱甘肽水平迅速下降^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

262.30

C₁₅H₁₈O₄

6754-13-8

固体

White to yellow

Room temperature in continental US; may vary elsewhere.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23(2):159-69.  [Content Brief]

  [2]. Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273(50):33508-16.  [Content Brief]

  [3]. Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105(3):913-21.  [Content Brief]