Hyodeoxycholic acid sodium  (Synonyms: HDCA sodium)

Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells^[1][2].

Hyodeoxycholic acid sodium 是由肠道菌群在小肠中形成的次级亲水性胆汁酸，作为 TGR5 的激动剂，在 CHO 细胞中的 EC₅₀ 为 31.6 μM^[1]。
Hyodeoxycholic acid (50，100 μM) sodium 增加参与 RAW 264.7 细胞胆固醇流出的基因 (Abca1、Abcg1 和 Apoe) 的表达^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hyodeoxycholic acid (HDCA；1.25% (wt/wt)) sodium 在 LDLRKO 小鼠中明显减少脂肪量并增加瘦体重，但不会提高任何器官毒性标志物的血清水平。Hyodeoxycholic acid 在 LDLRKO 的多个部位抑制动脉粥样硬化病变的形成，改善血浆脂蛋白谱，降低血浆葡萄糖水平和肠道胆固醇吸收效率，并通过粪便排出增加每日胆固醇排泄。Hyodeoxycholic acid sodium 还可以改善 HDL 功能，这可通过胆固醇流出测定法来衡量^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

414.55

C₂₄H₃₉NaO₄

10421-49-5

猪去氧胆酸钠

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41.  [Content Brief]

  [2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17.  [Content Brief]