2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Hyp9

Hyp9 是一种瞬时受体电位阳离子通道 6 (TRPC6) 特异性激动剂。Hyp9 可用于脊髓损伤 (SCI) 的研究。

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Hyp9 Chemical Structure

Hyp9 Chemical Structure

CAS No. : 3118-34-1

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规格 价格 是否有货 数量
1 mg ￥1152
1 - 2 周
5 mg ￥2879
1 - 2 周
10 mg   询价  
50 mg   询价  

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Hyp9 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1].

体外研究
(In Vitro)

HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) 以剂量依赖性方式抑制星形胶质细胞增殖[1]。
HYP9 显著抑制 AP4 过表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hyp9 相关抗体:

Cell Proliferation Assay[1]

Cell Line: CTX-TNA2 rat astrocytes
Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM
Incubation Time: 72 h
Result: Significantly inhibit astrocyte proliferation at 5-30 µM.
体内研究
(In Vivo)

HP9（鞘内注射；5 μg；1、3、5 和 7 天）通过抑制 SCl 大鼠体内模型中的 AQP4 来抑制星形胶质细胞的活化和增殖，并在 SCI 后保持神经元存活和功能恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1]
Dosage: 5 μg
Administration: Intrathecally; 1, 3, 5, and 7 days
Result: Inhibited activation and proliferation of astrocytes in a rat SCI model.
Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway.
Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats.
分子量

322.40

Formula

C18H26O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hyp9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hyp93118-34-1Hyp 9Hyp-9TRP ChannelTransient receptor potential channelstransient receptor potential canonical 6 (TRPC6)spinal cord injury (SCI)AQP4Inhibitorinhibitorinhibit

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